Abstract：Objective：To observe the clinical effect of Shexiang Baoxin pills combined with trimetazidine dihydrochloride modified release tablets for angina pectoris after percutaneous coronary intervention(PCI). Methods：A total of 120 cases of patients with angina pectoris after PCI were selected and divided into the observation group and the control group according to the random number table method，60 cases in each group. Both groups were given routine nursing；the control group was additionally given trimetazidine dihydrochloride modified release tablets， and the observation group was additionally given Shexiang Baoxin pills based on the treatment of the control group. The clinical effect was compared between the two groups. The frequency and duration of angina pectoris seizure before and after treatment were counted. The value of ejection fraction (EF) of the heart at different time points was detected. Results： The total effective rate was 98.33% in the observation group， and 88.33% in the control group， the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the frequency and duration of angina pectoris seizure between the two groups(P＞0.05). After treatment， the frequency of angina pectoris seizure in the two groups was lower than that before treatment，and the duration was shorter；the frequency of angina pectoris seizure in the observation group was lower than that in the control group，and the duration was shorter；differences were significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of EF value between the two groups(P＞0.05). After one- week and four- week treatment，EF values in the two groups were gradually increased，and the value in the observation group was higher than that in the control group at the same time point， the difference being significant(P＜0.05). Conclusion： In the treatment of patients with angina pectoris after PCI， the therapy of Shexiang Baoxin pills combined with trimetazidine dihydrochloride modified release tablets can significantly improve the heart function， lower frequency of angina pectoris seizure，and shorten the duration.