Abstract： Objective： To observe the effect of Chinese medicine rehabilitation nursing on quality of life， anxiety and depression of patients with cerebral infarction. Methods：A total of 78 cases of patients with cerebral infarction who were admitted and treated from August 2017 to August 2018 were selected and divided into the routine group and the study group according to the random number table method，39 cases in each group. The routine group was given routine nursing，and the study group was given Chinese medicine rehabilitation nursing. The clinical effect was compared. Results： There was significant difference being found in the comparison of scores of quality of life between the two groups(P＜0.05). Before intervention，when compared scores of Self-rating Anxiety Scale(SAS) and Self-rating Depression Scale(SDS) between the two groups， there was no significance being found in the difference(P＞0.05). After intervention， condition of anxiety and depression in the two groups was significantly improved，and the scores of SAS and SDS in the study group were lower than those in the control group(P＜0.05). Activities of daily living and score of degree of neurological deficit in the study group were better than those in the control group(P＜0.05). Conclusion：The application of Chinese medicine rehabilitation nursing in the treatment of patients with cerebral infarction has a positive effect on the improvement of their mental health status and quality of life. Meanwhile，it can improve their limb function and living ability，thus it has high clinical application value.