左归补髓生血汤对阴虚毒瘀型急性髓系白血病患者增效减毒的影响
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R733.71

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Effect of Effect-Enhancing and Toxicity-Reducing Function of Zuogui Busui Shengxue Tang on Patients with Acute Myeloid Leukemia of Yin Deficiency and Toxic Stasis Type
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    摘要:

    目的:研究左归补髓生血汤对阴虚毒瘀型急性髓系白血病患者增效减毒功能的影响。方法:将阴虚毒瘀型急性髓系白血病患者116 例,按照治疗方式分为对照组(58 例),试验组(58 例)。对照组给予联合序贯化疗方案,试验组在对照组治疗基础上加服左归补髓生血汤。2 组患者均连续治疗21 d。对比2 组治疗前后体力、白细胞计数、乏力、出血、骨痛、发热状况,血红蛋白、血液学毒性、血小板计数及输血依赖性;观察2 组患者治疗后的恢复情况及不良反应情况。结果:对照组总有效率为58.6%,试验组总有效率为77.6%,试验组疗效明显高于对照组,差异有统计学意义(P<0.05)。治疗后,对照组体力状况及输血依赖情况与治疗前比较,差异无统计学意义(P>0.05)。试验组体力状况及输血依赖情况较治疗前改善且优于对照组(P<0.05)。治疗后,2 组主要临床症状乏力、出血、发热、骨痛明显改善,试验组改善效果优于对照组(P<0.05)。治疗后,2 组血小板计数、白细胞计数、血红蛋白均有所改善,试验组改善效果优于对照组(P<0.05)。治疗后,2 组贫血、中性粒细胞减少、淋巴细胞减少比较,差异有统计学意义(P<0.05)。2 组不良反应主要有厌食、呕吐、乏力、腹胀,试验组不良反应发生率低于对照组(P<0.05)。结论:左归补髓生血汤对阴虚毒瘀型急性髓系白血病患者起增效减毒的作用,能有效改善患者的临床症状。

    Abstract:

    Abstract: Objective: To study the effect of Zuogui Busui Shengxue tang on effect- enhancing and toxicity- reducing function of patients with acute myeloid leukemia of yin deficiency and toxic stasis type. Methods: A total of 116 cases of patients with acute myeloid leukemia of yin deficiency and toxic stasis type were divided into the control group and the experiment group according to different treatment methods, 58 cases in each group. The control group was treated with combined sequenced chemotherapy scheme, and the experiment group was additionally treated with Zuogui Busui Shengxue tang based on the treatment of the control group. Both groups were continuously treated for 21 days. Physical strength,white blood cell count,fatigue,bleeding,bone pain,fever,hemoglobin,hematological toxicity,platelet count and transfusion dependence before and after treatment were compared between the two groups. The progress of recovery and condition of adverse reactions after treatment were observed in the two groups. Results: The total effective rate was 77.6% in the experiment group,significantly higher than that of 58.6% in the control group,the difference being significant (P<0.05). In the control group,when compared physical strength and transfusion dependence before and after treatment, there was no significance in the difference(P>0.05). After treatment, physical strength and transfusion dependence in the experiment group were improved when compared with those before treatment, and were better than those in the control group(P<0.05). After treatment,the main clinical symptoms,namely,fatigue,bleeding,fever and bone pain in the two groups were significantly improved,and the improvement in the experiment group was better than that in the control group (P<0.05). After treatment,platelet count,white blood cell count and hemoglobin in the two groups were improved,and the improvement in the experiment group was better than that in the control group(P<0.05). After treatment,when compared anemia, neutropenia, lymphopenia between the two groups, there was significance in the difference(P<0.05). The main adverse reactions in the two groups included loss of appetite, vomiting, fatigue and abdominal distension, and the incidence of adverse reactions in the experiment group was lower than that in the control group(P<0.05). Conclusion:The therapy of Zuogui Busui Shengxue tang has an effect-enhancing and toxicity-reducing effect on patients with acute myeloid leukemia of yin deficiency and toxic stasis type,and can effectively improve their clinical symptoms.

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杨莹,关红梅,王舒,刘冰,陈宛丽.左归补髓生血汤对阴虚毒瘀型急性髓系白血病患者增效减毒的影响[J].新中医,2021,53(8):111-114

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  • 在线发布日期: 2021-04-29
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