Abstract： Objective： To study the effect of Zuogui Busui Shengxue tang on effect- enhancing and toxicity- reducing function of patients with acute myeloid leukemia of yin deficiency and toxic stasis type. Methods： A total of 116 cases of patients with acute myeloid leukemia of yin deficiency and toxic stasis type were divided into the control group and the experiment group according to different treatment methods， 58 cases in each group. The control group was treated with combined sequenced chemotherapy scheme， and the experiment group was additionally treated with Zuogui Busui Shengxue tang based on the treatment of the control group. Both groups were continuously treated for 21 days. Physical strength，white blood cell count，fatigue，bleeding，bone pain，fever，hemoglobin，hematological toxicity，platelet count and transfusion dependence before and after treatment were compared between the two groups. The progress of recovery and condition of adverse reactions after treatment were observed in the two groups. Results： The total effective rate was 77.6% in the experiment group，significantly higher than that of 58.6% in the control group，the difference being significant (P＜0.05). In the control group，when compared physical strength and transfusion dependence before and after treatment， there was no significance in the difference(P＞0.05). After treatment， physical strength and transfusion dependence in the experiment group were improved when compared with those before treatment， and were better than those in the control group(P＜0.05). After treatment，the main clinical symptoms，namely，fatigue，bleeding，fever and bone pain in the two groups were significantly improved，and the improvement in the experiment group was better than that in the control group (P＜0.05). After treatment，platelet count，white blood cell count and hemoglobin in the two groups were improved，and the improvement in the experiment group was better than that in the control group(P＜0.05). After treatment，when compared anemia， neutropenia， lymphopenia between the two groups， there was significance in the difference(P＜0.05). The main adverse reactions in the two groups included loss of appetite， vomiting， fatigue and abdominal distension， and the incidence of adverse reactions in the experiment group was lower than that in the control group(P＜0.05). Conclusion：The therapy of Zuogui Busui Shengxue tang has an effect-enhancing and toxicity-reducing effect on patients with acute myeloid leukemia of yin deficiency and toxic stasis type，and can effectively improve their clinical symptoms.