益气养阴法治疗气阴两虚型晚期肺癌临床研究
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R734.2

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Clinical Study on Yiqi Yangyin Method for Advanced Lung Cancer of Qi-Yin Deficiency Type
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    摘要:

    目的:观察益气养阴法对气阴两虚型晚期肺癌患者生活质量的影响。方法:选择气阴两虚型晚期肺癌患者78 例,采用随机数字表法分为对照组和观察组各39 例。对照组行常规西医治疗,观察组在对照组基础上加用沙参麦门冬汤治疗。比较2 组中医证候积分、血清皮质醇和促肾上腺皮质激素水平、生活质量和生存情况。结果:治疗前,2 组中医证候积分比较无统计学差异(P>0.05)。治疗后,2 组中医证候积分较治疗前下降,且观察组中医证候积分低于对照组(P<0.05)。治疗前,2 组血 清皮质醇、促肾上腺皮质激素水平比较无统计学差异(P>0.05)。治疗后,2 组血清皮质醇均明显升高,但观察组升高幅度更明显;促肾上腺皮质激素均明显下降,但观察组下降更明显(P<0.05)。治疗前,2 组各项生活质量评分比较,差异无统计学意义(P>0.05)。治疗后,2 组躯体功能、情绪功能、认知功能、角色功能、社会功能评分均明显提高,但观察组提高更明显(P<0.05)。对照组中位生存时间为15 个月(95%CI:13.57~16.43 个月),短于观察组的21 个月(95%CI:18.41~23.59 个月),差异有统计学意义(P<0.05)。结论:益气养阴法联合常规西医治疗可明显改善气阴两虚型晚期肺癌患者中医证候积分,提高患者生活质量,提升血清皮质醇含量,降低促肾上腺皮质激素水平,延长患者生存期。

    Abstract:

    Abstract: Objective: To observe the effect of Yiqi Yangyin method on quality of life of patients with advanced lung cancer of qi-yin deficiency type. Methods:A total of 78 cases of patients with advanced lung cancer of qi-yin deficiency type were selected and divided into the control group and the observation group according to the random number table method, 39 cases in each group. The control group was given routine western medicine treatment,and the observation group was additionally given Shashen Maimendong tang based on the treatment of the control group. Chinese medicine syndrome scores, levels of serum cortisol and adrenocorticotropic hormone, quality of life, and survival condition were compared between the two groups. Results:Before treatment,there was no significant difference being found in the comparison of Chinese medicine syndrome scores between the two groups(P>0.05). After treatment,Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment, and the scores in the observation group were lower than that in the control group(P<0.05). Before treatment, when compared levels of serum cortisol and adrenocorticotropic hormone between the two groups, there was no significance in the difference(P>0.05). After treatment,levels of serum cortisol in the two groups were significantly increased,but the increase in the observation group was more significant; levels of adrenocorticotropic hormone in the two groups were significantly decreased, but the decrease in the observation group was more significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of each score of quality of life between the two groups(P>0.05). After treatment,scores of physical function, emotional function, cognitive function, role function, and social function in the two groups were significantly increased,but the increase in the observation group was more significant(P<0.05). The median survival time was 15 months (95%CI: 13.57~16.43 months) in the control group, shorter than that of 21 months(95%CI: 18.41~23.59 months) in the observation group, differences were significant(P<0.05). Conclusion: For patients with advanced lung cancer of qi- yin deficiency type,the therapy of Yiqi Yangyin method combined with routine western medicine can significantly improve their Chinese medicine syndrome scores, enhance their quality of life, increase content of serum cortisol, reduce level of adrenocorticotropic hormone,and prolong survival time.

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沈礼平,徐力.益气养阴法治疗气阴两虚型晚期肺癌临床研究[J].新中医,2021,53(8):107-110

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  • 在线发布日期: 2021-04-29
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