桃红四物汤合三子养亲汤加减治疗气滞血瘀型晚期非小细胞肺癌咳喘临床研究
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R734.2

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宁波市镇海区科技局项目(2015011)


Clinical Study on Modified Taohong Siwu Tang and Sanzi Yangqin Tang for Cough with Asthma in Advanced Non- Small Cell Lung Cancer of Qi Stagnation and Blood Stasis Type
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    摘要:

    目的:观察桃红四物汤合三子养亲汤加减治疗气滞血瘀型晚期非小细胞肺癌(NSCLC) 咳喘的临床疗效。方法:选取晚期NSCLC 咳喘患者86 例,按随机数字表法分为观察组和对照组各43 例。对照组给予常规西医治疗,观察组在对照组基础上给予桃红四物汤合三子养亲汤加减治疗。比较2 组治疗前后的咳痰缓解率、肺功能、Karnofsky(KPS) 生活质量评分及不良反应。结果:治疗后,观察组和对照组的咳痰缓解率分别为83.72%和62.79%,观察组明显高于对照组(P<0.05)。治疗后,2 组用力肺活量(FVC)、第1 秒用力呼气容积(FEV1) 和呼气峰流速(PEF) 明显高于治疗前(P<0.05),且观察组FVC、FEV1、PEF 均高于对照组(P<0.05)。治疗后,2 组KPS 评分较治疗前升高(P<0.05),且观察组KPS 评分高于对照组(P<0.05)。结论:桃红四物汤合三子养亲汤加减治疗晚期NSCLC 咳喘患者临床疗效较好,能够有效改善患者肺功能,提高患者生活质量。

    Abstract:

    Abstract:Objective:To observe the clinical effect of modified Taohong Siwu tang and Sanzi Yangqin tang for cough with asthma in advanced non-small cell lung cancer(NSCLC) of qi stagnation and blood stasis type. Methods:A total of 86 cases of cough with asthma in advanced NSCLC patients were divided into the observation group and the control group according to the random number table method,43 cases in each group. The control group was treated with routine western medicine, and the observation group was additionally treated with modified Taohong Siwu tang and Sanzi Yangqin tang based on the treatment of the control group. The remission rate of expectoration, the lung function and the scores of quality of life in Karnofsky(KPS) before and after treatment and the adverse reactions in the two groups were compared. Results: After treatment,the remission rate of expectoration was 83.72% in the observation group,significantly higher than that of 62.79% in the control group(P<0.05). After treatment,forced vital capacity(FVC),forced expiratory volume in one second(FEV1) and peak expiratory flow(PEF) in the two groups were significantly higher than those before treatment(P<0.05),and the above indexes in the observation group were higher than those in the control group(P<0.05). After treatment,KPS scores in the two groups were increased when compared with those before treatment(P<0.05), and the KPS score in the observation group was higher than that in the control group(P<0.05). Conclusion:Modified Taohong Siwu tang and Sanzi Yangqin tang has good clinical effect for cough with asthma in advanced NSCLC patients,which can effectively improve the lung function and quality of life.

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张渊,周珂玮,王邦才.桃红四物汤合三子养亲汤加减治疗气滞血瘀型晚期非小细胞肺癌咳喘临床研究[J].新中医,2021,53(8):103-106

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  • 在线发布日期: 2021-04-29
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