Abstract： Objective： To discuss and study the effect of Zishen Roujing tang on renal tubular injury and microinflammatory state in patients with gouty nephropathy complicated with renal failure and its curative effect. Methods：A total of 102 cases of patients with gouty nephropathy complicated with renal failure were enrolled as the study objects， and divided into the observation group and the control group based on different treatment methods，51 cases in each group. The control group was given basic treatment，and the observation group was additionally given Zishen Roujing tang based on the treatment of the control group. The curative effect was recorded in the two groups. Levels of albumin(Alb)，serum creatinine (SCr) ， blood urea nitrogen(BUN) ， urea nitrogen(UA) ， β2-microglobulin( β2-MG) ， 24-hour urine protein quantification (24 hUpro)，α1-microglobulin(α1-MG)，estimated glomerular filtration rate(eGFR)，hypersensitivity C-reaction protein(hs- CRP)，interleukin-6(IL-6)，tumor necrosis factor-α(TNF-α)，and monocyte chemotactic protein-1(MCP-1) were recorded in the two groups. Results：Before treatment，when compared levels of Alb，UA，SCr，and BUN between the two groups (P＞0.05). After treatment，levels of UA，SCr，and BUN in the two groups were decreased，and level of Alb was increased (P＜0.05). After treatment， levels of UA， SCr， and BUN in the observation group were lower than those in the control group， and level of Alb was higher than that in the control group(P＜0.05). Before treatment， when compared levels of eGFR，24 hUpro，α1-MG，and β2-MG between the two groups(P＞0.05). After treatment，levels of 24 hUpro，α1-MG， and β2-MG in the two groups were decreased ， and level of eGFR was increased(P＜0.05). After treatment， levels of 24 hUpro，α1-MG，and β2-MG in the observation group were lower than those in the control group，and level of eGFR was higher than that in the control group(P＜0.05). Before treatment，when compared levels of MCP-1，TNF- α，IL-6，and hs- CRP between the two groups(P＞0.05). After treatment， levels of MCP- 1， TNF- α， IL- 6， and hs- CRP in the two groups were decreased，and the levels above in the observation group were lower than those in the control group(P＜0.05). The total effective rate was 88.24% in the observation group， higher than that of 66.67% in the control group(P＜0.05). Conclusion：For patients with gouty nephropathy complicated with renal failure，Zishen Roujing tang can relieve renal tubular injury，significantly improve their micro-inflammatory state，and enhance the curative effect.