Abstract：Objective：ToobservethecurativeeffectofYiqiTongmaiJieduprescriptiononpatientswithmyocardial infarctionanditseffectonangiogenesisindexes. Methods：Atotalof 96 patientswithmyocardialinfarctionweredividedinto twogroups.Thecontrolgroupwasgivenconventionalsymptomatictreatment，andtheobservationgroupwasadditionally givenYiqiTongmaiJieduprescriptionbasedonthetreatmentofthecontrolgroup.Theclinicaleffectinthetwogroupswas analyzedaftertreatment. Results：Therewasnosignificantdifferenceinthecomparisonoftheangiogenesisindexesand inflammatorycytokinesbetweenthetwogroupsbeforetreatment(P＞0.05).Aftertreatment， thelevelsofvascular endothelialgrowthfactor(VEGF)andbasicfibroblastgrowthfactor(bFGF)intheobservationgroupwerehigherthanthosein thecontrolgroup，andthelevelsofendothelin(ET)，high-sensitivityC-reactiveprotein(hs-CRP)andtumornecrosisfactor-α (TNF-α)inobservationgroupwerelowerthanthoseinthecontrolgroup(P＜0.05).Beforetreatment，therewasnosignificant differenceinthecomparisonoftheleftventricularejectionfractionandmyocardialinfarctionareabetweenthetwogroups(P＞ 0.05).Aftertreatment，theleftventricularejectionfraction(65.96±4.85)%intheobservationgroupwaslargerthanthatinthe controlgroupandthemyocardialinfarctarea(26.85±3.11)%wassmallerthanthatinthecontrolgroup(P＜0.05).Thetotal effectiveratewas 95.83%intheobservationgroup，higherthanthatof 83.33%inthecontrolgroup，thedifferencebeing significant(P＜0.05). Conclusion：YiqiTongmaiJieduprescriptioncanpromoteangiogenesis，establishcollateralcirculation， lesseninflammationandreduceinfarctareainpatientswithmyocardialinfarction.