Abstract：Objective：ToobservetheclinicaleffectofpenetrationtherapywithmodifiedXiaoqinglongtangforchildren bronchiolitisofwind-coldfetteringthelungtype. Methods：Atotalof 98 casesofchildrenwithbronchiolitisofwind-cold fetteringthelungtypeweredividedintothecontrolgroupandtheobservationgroupaccordingtotherandomnumbertable method，49 casesineachgroup.Thecontrolgroupwastreatedwithcomprehensiveandsymptomatictreatment，andthe observationgroupwasadditionallytreatedwithpenetrationtherapywithmodifiedXiaoqinglongtangbasedonthetreatment ofthecontrolgroup.Aftertwo-weektreatment，ChinesemedicinesyndromescoresandlevelsofimmunoglobulinsA(IgA)， immunoglobulinsG(IgG)，immunoglobulinsM(IgM)beforeandaftertreatmentwerecomparedbetweenthetwogroups. Levelsofinflammatorycytokines，namely，interleukin-6(IL-6)，interleukin-8(IL-8)andtumornecrosisfactor-α(TNF-α) beforeandaftertreatmentwerecomparedbetweenthetwogroups. Results：Aftertreatment，syndromescoresofcough， excessiveexcretionofphlegmanddrool，rednessofpharynxanddrymouth，asthmaandpanting，andagitationandfeverin thetwogroupsweredecreasedwhencomparedwiththosebeforetreatment(P＜0.05)，andeachscoreintheobservation groupwaslowerthanthatinthecontrolgroup(P＜0.05).Aftertreatment，levelsofIgAandIgGinthetwogroupswere increasedwhencomparedwiththosebeforetreatment(P＜0.05)，andthetwolevelsintheobservationgroupwerehigher thanthoseinthecontrolgroup(P＜0.05)；levelsofIgMinthetwogroupsdidnotchangemuchbeforeandaftertreatment(P＞ 0.05).Aftertreatment，levelsofIL-6，IL-8 andTNF-α inthetwogroupsweredecreasedwhencomparedwiththosebefore treatment(P＜0.05)，andeachindexintheobservationgroupwaslowerthanthatinthecontrolgroup(P＜0.05). Conclusion： Inthetreatmentofchildrenbronchiolitisofwind-coldfetteringthelungtype，penetrationtherapywithmodifiedXiaoqinglong tangcaneffectivelyimproveclinicalsymptoms，suchasfeverandcough，enhancechildren'simmunity，andimprovelevels ofinflammatoryfactors.