Abstract：Objective：TodiscussthemechanismofextractofFoliumGinkgoinhibitingcellapoptosisinhippocampusof ratswithintractableepilepsy. Methods： SDratsweredividedintothecontrolgroup， themodelgroup， andthe administrationgroup.Exceptforthecontrolgroup，intheothergroups，modelswithintractableepilepsywereestablished. Aftersuccessfulestablishment，theadministrationgroupwasgivengastricperfusionofextractofFoliumGinkgoatthedose of 60 mg/(kg·d)；thecontrolgroupandthemodelgroupweregivennormalsalineofthesamevolume；thetreatmentlasted forfourweeksinthethreegroups.Behaviorwasobservedineachgroup.Thefrequencyandthetotaltimeofepilepsyseizure wererecorded.Racinstandardwasusedforgradingepilepsyseizureofrats.Westernblotwasusedtodetecttheexpression levelofproteinofcleaved-cysteinylaspartatespecificproteinase 3(Cleaved-Caspase 3)， cysteinylaspartatespecific proteinase 3(Caspase 3)，cleaved-cysteinylaspartatespecificproteinase 9(Cleaved-Caspase 9)，cysteinylaspartatespecific proteinase 9(Caspase 9)，proteinkinaseB(Akt)，phosphorylated-proteinkinaseB(p-Akt)，translationinitiationfactor 4E bindingprotein 1(4EBP1)， phosphorylated-translationinitiationfactor 4Ebindingprotein 1(p- 4EBP1)， phosphorylated- ribosomalproteinS6 kinase(p-S6K)，andribosomalproteinS6 kinase(S6K)ineachgroup. Results：Comparedwiththosein thecontrolgroup，thefrequencyandthetotaltimeofepilepsyseizureaswellasseizuregradeinthemodelgroupwere increased(P＜0.05).Comparedwiththoseinthemodelgroup，thefrequencyandthetotaltimeofepilepsyseizureaswellas seizuregradeintheadministrationgroupweredecreased(P＜0.05).Comparedwiththoseinthecontrolgroup，inthemodel group，theexpressionofproteinofCaspase 9，Caspase 3，p-Akt/Akt，p-4EBP1/4EBP1，andp-S6K/S6Kwasdecreased (P＜0.05)，andtheexpressionofproteinofCleaved-Caspase 9 andCleaved-Caspase 3 wasincreased(P＜0.05).Compared withthoseinthemodelgroup，intheadministrationgroup，theexpressionofproteinofCaspase 9，Caspase 3，p-Akt/Akt， p-4EBP1/4EBP1，andp-S6K/S6Kwasincreased(P＜0.05)，andtheexpressionofproteinofCleaved-Caspase 9 and Cleaved-Caspase 3 wasdecreased(P＜0.05). Conclusion：ExtractofFoliumGinkgocansignificantlyinhibitepilepsyseizureof ratswithintractableepilepsy，andalleviatecellapoptosisinhippocampus.Themechanismisprobablyrelatedtothefinding thatextractofFoliumGinkgocansignificantlyactivatetheexpressionofAkt/mammaliantargetofrapamycin(mTOR)pathway.