清利化浊方联合三联灭菌疗法治疗慢性胃炎伴幽门螺杆菌感染临床研究
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R573.3+9

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国家中医药管理局全国基层名老中医药专家传承工作室建设项目(国中医药人教函[2015]174号)


Clinical Study on Qingli Huazhuo Prescription Combined with Triple Therapy for Chronic Gastritis Complicated with Helicobacter Pylori Infection
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    摘要:

    目的:观察清利化浊方联合三联杀菌疗法治疗慢性胃炎伴幽门螺杆菌感染的临床疗效。方法:将 60 例慢性胃炎伴幽门螺杆菌感染患者随机分为观察组和对照组各 30 例。对照组给予三联灭菌法治疗,观察组在对照组的基础上给予清利化浊方治疗,2 周为 1 个疗程,共治疗 2 个疗程。观察比较 2 组临床疗效、幽门螺杆菌根除情况、不良反应及复发情况。结果:观察组总有效率为 96.7%,对照组为 76.7%,2 组比较,差异有统计学意义 (P<0.05)。观察组幽门螺杆菌根除率为 96.7%,对照组为70.0%,2 组比较,差异有统计学意义(P<0.05)。治疗后,2 组症状积分均较治疗前降低(P<0.05);且观察组症状积分低于对照组(P<0.05)。不良反应发生率、复发率观察组分别为 6.7%、3.4%,对照组分别为 16.7%、17.4%,2 组比较,差异有统计学意义(P<0.05)。结论:清利化浊方联合三联杀菌疗法治疗慢性胃炎伴幽门螺杆菌感染优于三联杀菌疗法治疗,且不良反应发生率及复发率均较低。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Qingli Huazhuo prescription combined with triple therapy for chronic gastritis complicated with helicobacter pylori(Hp) infection. Methods:A total of 60 patients with chronic gastritis complicated with Hp infection were randomly divided into the observation group and the control group, 30 cases in each group. The control group was given triple therapy,and the observation group was additionally given Qingli Huazhuo prescription based on the treatment of the control group. Both groups were treated for two courses,two weeks being one course. The clinical effect, Hp eradication rate, adverse reactions and recurrence were observed and compared between the two groups. Results:The total effective rate was 96.7% in the observation group and 76.7% in the control group,the difference being significant(P<0.05). The Hp eradication rate was 96.7% in the observation group and 70.0% in the control group, the difference being significant(P<0.05). After treatment,the symptom scores in both groups were decreased when compared with those before treatment(P<0.05),and the symptom score in the observation group was lower than that in the control group(P<0.05). The incidence of adverse reactions and recurrence rate were respectively 3.4% and 6.7% in the observation group and respectively 17.4% and 16.7% in the control group,the difference being significant(P<0.05). Conclusion:Qingli Huazhuo prescription combined with triple therapy is better than triple therapy when treating Hp infection,whose incidence of adverse reactions and recurrence rate is low.

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李菁,陈慧.清利化浊方联合三联灭菌疗法治疗慢性胃炎伴幽门螺杆菌感染临床研究[J].新中医,2021,53(7):73-76

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  • 在线发布日期: 2021-04-08
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