Abstract：Objective：To observe the effect of point application on the nursing of patients with non-invasive ventilation in the intensive care unit(ICU). Methods：A total of 60 patients who underwent non-invasive ventilation were divided into two groups according to the random number table method，30 cases in each group. The control group received ordinary routine nursing，and the observation group performed symptomatic nursing such as point application based on the nursing plan of the control group. The incidence of delirium and abdominal distension in the two groups during nursing was observed. Results： After nursing，the score of the Confusion Assessment Method- Chinese Reversion(CAM-CR) and the incidence of delirium and the abdominal distension in the observation group were lower than those in the control group(P＜0.05). Conclusion： Point application can reduce the incidence of delirium and abdominal distension in nursing patients with non- invasive ventilation in ICU.