Abstract： Objective： To observe the clinical effect of Qingre Juanbi tang combined with methotrexate for rheumatoid arthritis of damp- heat obstruction type. Methods：A total of 134 cases of patients with rheumatoid arthritis of damp- heat obstruction type were selected and divided into the observation group and the control group according to the random number table method，67 cases in each group. The control group was treated with routine western medicine，and the observation group was additionally treated with Qingre Juanbi tang based on the treatment of the control group. The clinical effect in the two groups was compared；Chinese medicine syndrome scores were counted；the levels of α1-acid glycoprotein(α1-AGP)， tumor necrosis factor ligand-related molecule 1 A(TL1A)，C-reactive protein(CRP)，interleukin-17(IL-17) and interleukin-1 (IL- 1) in serum before and after treatment were detected. Results：The total effective rate was 91.04% in the observation group，higher than that of 76.12% in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of Chinese medicine syndrome scores(P＞0.05). After treatment， the scores of joint swelling and pain，difficulty in extension and flexion，morning stiffness，and thirst and sweating in the two groups were lower than those before treatment(P＜0.05)， and the above scores in the observation group were lower than those in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of α1-AGP，TL1A， CRP，IL-17 and IL-1 between the two groups(P＞0.05). After treatment，the levels of α1-AGP，TL1A，CRP，IL-17 and IL-1 in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above levels in the observation group were lower than those in the control group(P＜0.05). The incidence of adverse reactions was 4.48% in the observation group and 7.46% in the control group，there being no significance in the difference(P＞0.05). Conclusion：Qingre Juanbi tang combined with methotrexate for rheumatoid arthritis of damp- heat obstruction type has significant curative effect， and can improve clinical symptoms， reduce the expressions of α1- AGP in serum and TL1A， and relieve inflammatory responses without the increase of adverse reactions.