Abstract： Objective： To observe the effect of Guanxin Shutong capsules combined with rosuvastatin on long- term prognosis of senile patients with coronary heart disease after stenting and its effect on platelet function， as well as interleukin- 6(IL- 6) and tumor necrosis factor- α(TNF- α) in serum. Methods： A total of 123 cases of senile patients with coronary heart disease after stenting were divided into the control group and the study group according to the random number table method. The control group was given rosuvastatin，and the study group was additionally treated with Guanxin Shutong capsules based on the treatment of the control group. The clinical effect in the two groups was observed. Before and after treatment， the changes in the levels of platelet membrane P- selectin(CD62P)， lysosome associated membrane protein 3 (CD63) and platelet membrane glycoproteins Ⅱ b/Ⅲ a(GPⅡb/Ⅲa) as well as IL-6 and TNF-α in serum in the two groups were compared. After surgery， the incidences of postoperative cardiovascular adverse events and the reconstruction of target vessels in the two groups were analyzed. Results：The total effective rate was 90.16% in the study group，higher than that of 74.19% in the control group(P＜0.05). After treatment，the levels of CD62P，CD63 and GPⅡb/Ⅲa were lower than those before treatment(P＜0.05)，and the levels in the study group were lower than those in the control group(P＜0.05)；the levels of IL-6 and TNF-α in serum in the two groups were lower than those before treatment(P＜0.05)，and the levels in the study group were lower than those in the control group(P＜0.05)；the incidences of cardiovascular adverse events and target vessel revascularization in the study group were lower than those in the control group(P＜0.05). Conclusion：The therapy of Guanxin Shutong capsules combined with rosuvastatin for senile patients with coronary heart disease after stenting can effectively improve their prognosis and platelet function，and reduce the levels of IL-6 and TNF-α in serum.