Abstract：Objective：To observe the clinical effect of modified Lingjiao Gouteng tang combined with glycerin fructose for acute cerebral hemorrhage. Methods：A total of 105 cases of patients with acute cerebral hemorrhage were divided into the study group，the control group A and the control group B according to the random number table method，35 cases in each group. All groups were given basic treatment such as low flow oxygen inhalation， correction of water electrolyte balance， prevention of infection and protection of brain cells；the control group A was additionally treated with glycerin fructose，the control group B was additionally treated with modified Lingjiao Gouteng tang，and the study group was additionally treated with modified Lingjiao Gouteng tang combined with glycerin fructose. All groups were treated for one month. The National Institute of Health Stroke Scale(NIHSS) scores，the Barthel Index(BI)，the cerebral hematoma volume，the peripheral edema volume，the cerebral hemodynamic indexes and the levels of inflammatory factors in serum and nerve cell factors before and after treatment and the clinical effect in the three groups were compared. Results：The total effective rate was 94.29% in the study group，higher than those of 71.43% and 74.29% respectively in the control group A and B(P＜0.05). After treatment， NIHSS scores in the three groups were decreased when compared with those before treatment(P＜0.05)，and the score in the study group was lower than those in the control group A and B(P＜0.05)；the BI scores in the three groups were increased when compared with those before treatment(P＜0.05)，and the score in the study group was higher than those in the control group A and B(P＜0.05)； the cerebral hematoma volume and the peripheral edema volume in the three groups were decreased when compared with those before treatment(P＜0.05)，and the volumes in the study group were fewer than those in the control group A and B(P＜0.05). After treatment，the mean velocity(Vm)，end-diastolic velocity(Vd) and pulsatility index (PI) in the middle cerebral artery in the three groups were increased when compared with those before treatment(P＜0.05)， and the Vm，Vd and PI in the middle cerebral artery in the study group were higher than those in the control group A and B (P＜0.05)； the resistance index(RI) in the middle cerebral artery in the three groups were decreased when compared with those before treatment(P＜0.05)， and the RI in the middle cerebral artery in the study group were lower than those in the control group A and B(P＜0.05). After treatment，the levels of interleukin-1β(IL-1β)，matrix metalloproteinase- 9(MMP- 9)， high- sensitivity C- reactive protein(hs- CRP)，myelin basic protein(MBP)，S100B and neuron- specific enolase(NSE) in serum in the three groups were decreased when compared with those before treatment(P＜0.05)，and the levels of IL- 1β， MMP-9，hs-CRP，MBP，S100B and NSE in serum in the study group were lower than those in the control group A and B (P＜0.05). Conclusion： Modified Lingjiao Gouteng tang combined with glycerin fructose for acute cerebral hemorrhage has significant clinical effect and can effectively promote the reduction of cerebral hematoma and peripheral edema， improve cerebral blood flow state，relieve local inflammatory reactions，and protect nerve cell factors，so as to promote the recovery of nerve and activity function of patients.