Abstract： Objective： To observe the curative effect of modified Shipi yin and Zhenwu tang combined with routine western medicine for nephrotic syndrome(NS) with spleen- kidney yang deficiency syndrome and its effect on levels of Ddimer and cystatin C. Methods： A total of 100 cases of NS patients with spleen- kidney yang deficiency syndrome were selected and divided into the control group and the observation group according to the random number table method， 50 cases in each group. Both groups were given basic treatment，the control group was additionally given oral administration of prednisone acetate tablets， and the observation group was additionally treated with modified Shipi yin and Zhenwu tang based on the treatment of the control group. The treatment in the two groups lasted for continuous six months. Clinical effect，the kidney function indexes，scores of spleen-kidney yang deficiency syndrome，and levels of D-dimer and cystatin C were compared between the two groups. Results： The total effective rate was 84.0% in the observation group， higher than that of 64.0% in the control group(P＜0.05). Before treatment，when compared the levels of albumin，24-hour urinary protein excretion， blood urea nitrogen， and blood serum creatinine in serum between the two groups， there was no significance in the difference(P＞0.05). After treatment， the levels of albumin in the two groups were increased when compared with those before treatment，and the levels of 24-hour urinary protein excretion，blood urea nitrogen，and blood serum creatinine were decreased；the level of albumin in the observation group was higher than that in the control group， and the levels of 24-hour urinary protein excretion，blood urea nitrogen，and blood serum creatinine were lower than those in the control group；differences were significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of each symptom score of the spleen-kidney yang deficiency syndrome between the two groups(P＞0.05). After treatment， each symptom score of the spleen- kidney yang deficiency syndrome in the two groups were decreased when compared with those before treatment(P＜0.05)，and the scores in the observation group were all lower than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of D- dimer and cystatin C between the two groups(P＞0.05). After treatment， levels of D- dimer and cystatin C in the two groups were decreased when compared with those before treatment(P＜0.05)，and the levels in the observation group were lower than those in the control group(P＜0.05). Conclusion： The therapy of modified Shipi yin and Zhenwu tang combined with routine western medicine has significant curative effect in the treatment of NS with spleen- kidney yang deficiency syndrome，which can improve the kidney function and clinical symptoms，and effectively down-regulate levels of D-dimer and cystatin C.