Abstract：Objective：To observe the clinical effect of moxibustion on salt turtle shell at Shenque(CV8) combined with acupuncture for chronic urticaria. Methods： A total of 48 cases of patients with chronic urticaria were divided into the treatment group and the control group according to the random number table method， 25 and 23 cases in each group respectively. The treatment group was treated with moxibustion on salt turtle shell at Shenque(CV8) combined with acupuncture，and the control group was given acupuncture only. Both groups were treated for six weeks continuously，once every other day. Before and after treatment，the Urticaria Activity Score(UAS) and Dermatology Life Quality Index(DLQI) were compared between the two groups. The recurrence rate of chronic urticaria was counted three months after treatment. Results：After four weeks and six weeks of treatment，the UAS in the two groups were decreased when compared with those before treatment，differences being significant(P＜0.05). After six-week treatment，the UAS in the treatment group was lower than that in the control group，the difference being significant(P＜0.05). After six-week treatment，the DLQI in the two groups were decreased when compared with those before treatment，and the DLQI in the treatment group was lower than that in the control group，differences being significant(P＜0.05). According to the follow-up three months after treatment， the recurrence rate was 28.0% in the treatment group and 47.9% in the control group， the difference being significant(P＜0.05). Conclusion： The treatment of moxibustion on salt turtle shell at Shenque(CV8) combined with acupuncture for chronic urticaria has significant improvement on clinical symptoms and quality of life， with good curative effect and low recurrence rate.