Abstract：Objective：To observe the clinical effect of modified Wenyang Bushen tang combined with point stimulation in adjuvant therapy of bone metastases from prostate cancer，and to discuss its possible mechanism. Methods：A total of 54 cases of patients with bone metastases from prostate cancer were selected and divided into the observation group and the control group according to the random number table method，27 cases in each group. Due to disease progression and the loss to follow- up, there were 25 cases left in each group and completed the study. Both groups were given medical castration and antiandrogen medicine after surgery；the observation group was additionally treated with oral administration of Wenyang Bushen tang combined with point stimulation，and the control group was treated with analgesic medicine. Both groups were intervened for continuous 12 weeks and were followed up for 6 months. The clinical effect was compared between the two groups. The related indexes of bone metastases from prostate cancer，inflammation，pain degree，quality of life were compared between the two groups before and after treatment，and recorded adverse reactions. Results：The total effective rate was 40.00% in the observation group， and 28.00% in the control group， there was no significant difference between the two groups(P＞0.05). After treatment， the levels of alkaline phosphatase(ALP) in serum in both groups were increased when compared with those before treatment(P＜0.05)，and the ALP level in the observation group was lower than that in the control group(P＜0.05). After treatment，the levels of prostate-specific antigen(PSA) in serum and the scores of Verbal Rating Scale of pain(VRS) in the two groups were decreased when compared with those before treatment (P＜0.05)；the PSA level and VRS score in the observation group were lower than those of the control group(P＜0.05). After treatment， the scores of urination symptom， mental state， pain and gastrointestinal reactions in the two groups were decreased when compared with those before treatment(P＜0.05)， and the decrease in the four scores above in the observation group was more significant than that in the control group(P＜0.05). After treatment， the scores of activity limitation，psychological fluctuation，overall health and sleep in the two groups were increase when compared with those before treatment(P＜0.05)，and the increased in the four scores above in the observation group was more significant than that in the control group(P＜0.05). During the six- month follow- up after treatment， the rate of symptom exacerbation was 30.00% in the observation group，lower than that of 57.14% in the control group(P＜0.05). The VRS score of patients with symptom exacerbation was(5.64±1.86) in the observation group，lower than that of(6.71±2.25) in the control group(P＜0.05). After treatment，the levels of interleukin(IL)-1，IL-17，tumor necrosis factor-α(TNF-α) and matrix metalloproteinases-3 (MMP- 3) in serum in the two groups were decreased when compared with those before treatment(P＜0.01)， and the decrease in the four levels above in the observation group was more significant than that in the control group(P＜0.05). Conclusion： In the treatment of patients with bone metastases from prostate cancer， the adjuvant therapy of modified Wenyang Bushen tang combined with point stimulation can significantly relieve pain caused by bone metastasis， and enhance short-term curative effect and quality of life. Meanwhile，it can delay the progress of bone metastasis of prostate cancer and achieve good long- term curative effect. Its mechanism may be related to the inhibition of expression of inflammatory factors.