Abstract：Objective：To observe the effect of Bushen Jiangzhuo tang on kidney function and immune function in patients with chronic glomerulonephritis. Methods：A total of 98 cases of patients with chronic glomerulonephritis were divided into the control group and the observation group according to the random number table method，49 cases in each group. The control group was treated with routine western medicine，and the observation group was additionally treated with Bushen Jiangzhuo tang based on the treatment of the control group. Both groups were treated for eight weeks. The changes in clinical effect，total Chinese medicine syndrome scores，related indexes of kidney function including serum urea nitrogen，serum creatinine，24- hour urinary protein，1- hour urine red blood cell excreting rate，and related indexes of immune function including CD4 + ， CD8 + and CD4 +/CD8 + ， immunoglobulin A(IgA)， immunoglobulin G(IgG)， immunoglobulin M(IgM) and complement C3 in the two groups were compared. Results：The total effective rate was 91.84% in the observation group and 75.51% in the control group， the difference being significant(P＜0.05). After treatment， the total Chinese medicine syndrome scores in the two groups were significantly decreased when compared with those before treatment(P＜0.05)，and the score in the observation group was lower than that in the control group(P＜0.05). After treatment，serum urea nitrogen， serum creatinine，24- hour urinary protein，1- hour urine red blood cell excreting rate in the two groups were decreased when compared with those before treatment，and the indexes in the observation group were lower than those in the control group(P＜0.05). After treatment，the levels of CD8 + and IgA in the two groups were decreased when compared with those before treatment，and the levels of CD4+/CD8+，IgMand complementC3 were increased(P＜0.05)；the improvement of the above indexes in the observation group was more significant than that in the control group(P＜0.05). Conclusion：Bushen Jiangzhuo tang has definite curative effect in treating chronic glomerulonephritis，which can effectively relieve symptoms and improve kidney function and immune function of patients.