复方黄芪养心合剂治疗气虚血瘀型冠心病不稳定性心绞痛临床研究
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R541.4

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浙江省中医药科技计划项目(2016ZA148)


Clinical Study on Compound Astragalus Mixture Nourishing Heart for Coronary Heart Disease with Unstable Angina of Qi Deficiency with Blood Stasis Type
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    摘要:

    目的:观察复方黄芪养心合剂 (Compound astragalus mixture nourishing heart,CAMNH) 联合常规西药治疗,对气虚血瘀型冠心病不稳定性心绞痛患者中医证候积分及西雅图心绞痛量表(SAQ) 评分的影响。方法:选取 52 例气虚血瘀型冠心病不稳定性心绞痛患者,采用随机数字表法分为对照组和复方黄芪养心合剂组各 26 例,2 组均给予西医标准治疗方案,复方黄芪养心合剂组同时加用 CAMNH 治疗,治疗 4 周后比较 2 组中医证候积分及 SAQ 评分。结果:最终纳入统计对照组 26 例,复方黄芪养心合剂组 25 例。治疗后,2 组中医证候积分均较治疗前明显降低,差异有统计学意义(P<0.01)。2 组间比较,复方黄芪养心合剂组中医证候积分较对照组低,差异有统计学意义(P<0.01)。对照组躯体活动受限程度、心绞痛稳定状态、心绞痛发作情况、治疗满意程度 4 个维度评分均较治疗前升高,差异均有统计学意义 (P<0.01,P<0.05),疾病认识程度维度评分较治疗前稍升高,但差异无统计学意义 (P>0.05);复方黄芪养心合剂组的各维度评分均较治疗前升高,差异均有统计学意义 (P< 0.01,P<0.05)。2 组间比较,复方黄芪养心合剂组各维度评分改善均优于对照组,差异均有统计学意义 (P<0.01,P<0.05)。结论:CAMNH 可改善气虚血瘀型冠心病不稳定性心绞痛患者气虚血瘀证中医证候积分及 SAQ 评分,改善患者临床症状,提高生活质量。

    Abstract:

    Abstract:Objective:To observe the effect of Compound astragalus mixture nourishing heart(CAMNH) combined with routine western medicine on Chinese medicine syndrome scores and Seattle Angina Questionnaire(SAQ) scores in patients with coronary heart disease with unstable angina of qi deficiency with blood stasis type. Methods:A total of 52 cases of patients with coronary heart disease with unstable angina of qi deficiency with blood stasis type were selected and divided into the control group and the CAMNH group according to the random number table method,26 cases in each group. Both groups were given standard western medicine treatment,and the CAMNH group was additionally treated with CAMNH at the same time. After four weeks of treatment,Chinese medicine syndrome scores and SAQ scores in the two groups were compared. Results:In the end,26 cases in control group and 25 cases in the CAMNH group were included in the statistics. After treatment,Chinese medicine syndrome scores in the two groups were significantly decreased when compared with those before treatment,the difference being significant(P<0.01);the score in the CAMNH group was lower than that in the control group,the difference being significant(P<0.01). In the control group,the scores of physical activity limitation,stable state of angina pectoris, angina attacks and treatment satisfaction were all increased when compared with those before treatment,differences being significant(P<0.01,P<0.05);the scores of disease awareness were slightly increased,but the difference showed no significance(P>0.05). The scores in all dimensions in the CAMNH group were increased when compared with those before treatment,differences being significant (P<0.01,P<0.05). The comparison between the two groups showed that the improvement of scores in all dimensions in the CAMNH group was better than that in the control group, differences being significant(P<0.01, P<0.05). Conclusion: The application of Compound astragalus mixture nourishing heart for patients with coronary heart disease with unstable angina of qi deficiency with blood stasis type can improve their Chinese medicine syndrome scores,SAQ scores,clinical symptoms and quality of life.

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陈启兰,李梦茜,闪书华,王丽晴.复方黄芪养心合剂治疗气虚血瘀型冠心病不稳定性心绞痛临床研究[J].新中医,2021,53(4):65-69

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  • 在线发布日期: 2021-02-27
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