地黄用于消渴病研究进展
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R255.4

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河南省科技攻关计划项目(202102310188)


Research Progress of Radix Rehmanniae for Wasting-Thirst Disease
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    摘要:

    目的:通过从地黄在消渴方剂中的出现频率和现代药理学研究验证地黄在消渴病治疗中的重要作用。方法:检索中国知网、维普、万方和PubMed 等数据库中的相关文献,用Microsoft Excel 2010 对筛选的文献和数据进行归纳、整理,分析地黄在消渴病药方中的应用情况,不同证型消渴病中地黄炮制品的应用及应用差异,总结地黄在糖尿病治疗方面的活性成分研究及其降血糖的作用机制。结果:共得到含有地黄的消渴方剂41 首,其中生地黄占18 首,熟地黄占23 首。且所收集的方剂多出自《太平圣惠方》。在不同证候的消渴病方剂中,以阴虚燥热和气阴两虚型的治疗方剂中地黄的应用频率较高。对于地黄的不同炮制品,在阴虚燥热、阴虚热盛、气阴两虚型消渴病方剂中,生地黄的应用较熟地黄多,而在肝肾阴虚、气虚血瘀和阴阳两虚型消渴病中,熟地黄的应用较生地黄多。现代药理学文献分析得到地黄中所含有的降血糖活性成分主要为环烯醚萜类的梓醇、地黄多糖及寡糖类。结论:古代经典药方和现代药理学研究均表明,地黄治疗消渴病有较好的疗效。

    Abstract:

    Abstract: Objective:To verify the important role of Radix Rehmanniae in the treatment of wasting-thirst disease by studying the frequency of Radix Rehmanniae in wasting- thirst disease related prescriptions and modern pharmacology. Methods:Relevant literatures and data retrieved from CNKI,VIP,Wanfang and PubMed databases were summed up and sorted out via Microsoft Excel 2010. In this paper, the application of Radix Rehmanniae in wasting- thirst disease related prescriptions, the application of different processed products of Radix Rehmanniae in treating wasting- thirst disease of different syndrome types and their difference were analyzed, and the active components of Radix Rehmanniae in the treatment of wasting- thirst disease and its hypoglycemic mechanism were summarized. Results: A total of 41 Xiaoke prescriptions containing Rehmannia glutinosa were obtained,of which 18 were unprocessed Radix Rehmanniae and 23 were processed Radix Rehmanniae glutinosa. And most of the prescriptions collected are from Tai Ping Sheng Hui Fang. Among the prescriptions treating different syndromes,Radix Rehmanniae was more frequently used in the prescriptions for deficiency of both yin and yang type and deficiency of both qi and yin type. Among different processed products of Radix Rehmanniae, unprocessed Radix Rehmanniae was more frequently used in the prescriptions for yin deficiency and dryness-heat type,yin deficiency and excessive heat type and deficiency of both qi and yin type;processed Radix Rehmanniae was more frequently used in the prescriptions for liver-kidney yin deficiency type,qi deficiency and blood stasis type and deficiency of both yin and yang type. According to the analysis of literatures of modern pharmacology, the main hypoglycemic components in Radix Rehmanniae were catalpol, rehmannia glutinosa polysaccharide and oligosaccharides. Conclusion: Both ancient classical prescriptions and modern pharmacological studies show that Radix Rehmanniae has a good therapeutic effect on wastingthirst disease.

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王明琴,张雪荣,吴宿慧,孟雨帆,李寒冰.地黄用于消渴病研究进展[J].新中医,2021,53(4):19-24

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  • 在线发布日期: 2021-02-27
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