Abstract：Objective：To observe the nursing effect of Tongluo Xieding prescription combined with point application for patients with early type 2 diabetes complicated with lower extremity arterial disease. Methods：A total of 86 cases of patients with early type 2 diabetes complicated with lower extremity arterial disease were divided into two groups according the random number table method，43 cases in each group. The control group was given routine treatments including reducing blood glucose and blood lipid，and anti- platelet aggregation；the observation group was additionally given Tongluo Xieding prescription and point application based on the treatment of the control group. The Chinese medicine syndrome scores and the clinical effect before and after intervention were evaluated in the two groups. The level of fasting blood glucose before and after intervention was examined in the two groups. Ankle- brachial index(ABI)，pulsation index of dorsal artery of foot，and the mean blood flow velocity of dorsal artery of foot before and after intervention were examined in the two groups. The adverse reactions during treatment were recorded. Results： When compared the levels of fasting blood glucose and glycosylated hemoglobin between the two groups before intervention，there was no significance in the difference(P＞0.05). After intervention，the levels of fasting blood glucose and glycosylated hemoglobin in the two groups were lower than those before intervention，and the two levels in the observation group were lower than those in the control group(P＜0.05). When compared ABI and pulsation index of dorsal artery of foot between the two groups before intervention， there was no significance in the difference(P＞0.05). After intervention，ABI and pulsation index of dorsal artery of foot in the two groups were higher than those before intervention， and the two indexes in the observation group were better than those in the control group(P＜0.05). After intervention，the mean blood flow velocity of dorsal artery of foot in the two groups was higher than that before intervention，and the mean blood flow velocity in the observation group was higher than that in the control group(P＜0.05). After intervention， the Chinese medicine syndrome scores in the two groups were decreased when compared with those before intervention，and the decrease in the observation group was larger than that in the control group (P＜0.05). The total clinical effective rate was 90.70% in the observation group， higher than that of 69.77% in the control group， the difference being significant(P＜0.05). During treatment， there were no obvious adverse reactions in the two groups. Conclusion：In the treatment of patients with early type 2 diabetes complicated with lower extremity arterial disease， the therapy of Tongluo Xieding prescription combined with point application conduces to improving their clinical symptoms and blood rheology， retarding the development of atherosclerosis， and preventing further luminal stenosis， with significant curative effect and safety.