Abstract： The liver， the spleen， and the kidney are closely related and play a key role in the transmission process of cancer toxin. In the early stage of the liver cancer，cancer toxin begins to form，with the binding of toxin and stasis，as well as the liver depression and spleen deficiency. In the middle stage of the liver cancer，the growing binding of toxin and stasis results in the disharmony of the liver， the spleen， and the kidney. In the advanced stage of the liver cancer， there are diffusing cancer toxin，damage to the spleen qi，the deficiency of the liver and the kidney，negative effect on five viscera， dysfunction of viscera and bowels， and poor prognosis. From the perspective of the liver， the spleen， and the kidney， discusses the theory of cancer toxin transmission in the occurrence and development of primary liver cancer，and aims to find a method to block and delay the cancer toxin transmission based on the prevention and treatment experience of Chinese medicine for primary liver cancer and the core pathogenesis of cancer toxin causing deficiency.