Abstract： Objective： To observe the effect of Shentao Ruangan tablets combined with transcatheter arterial chemoembolization on liver function and tumor markers of patients with liver cancer. Methods：A total of 80 cases of patients with liver cancer were randomly divided into the control group and the observation group，40 cases in each group. The control group was treated with transcatheter arterial chemoembolization with pirarubicin(THP)， mitomycin C(MMC)， carboplatin (CBP) and lipiodol，and the observation group was additionally treated with Shentao Ruangan tablets based on the treatment of the control group. Both groups were treated for 30 days. The changes in levels of liver function including alanine aminotransferase(ALT)，aspartate aminotransferase(AST)，total bilirubin(TBil)，albumin(Alb)，prealbumin(PA) and lumbar disc herniation(LDH) as well as tumor markers including alpha- fetoprotein(AFP)， α- L- fucosidase(AFU) and carcinoembryonic antigen(CEA) in the two groups were compared. Results： After treatment， the levels of ALT， AST and LDH in the two groups were significantly decreased when compared with those before treatment(P＜0.05)， and the indexes in the observation group were lower than those in the control group(P＜0.05). After treatment， the TBil levels in the two groups were decreased when compared with those before treatment(P＜0.05)， and the levels of Alb and PA were increased(P＜ 0.05)；the improvement of the above indexes in the observation group was more significant than that in the control group(P＜ 0.05). After treatment，the levels of AFP，AFU and CEA in the two groups were significantly decreased when compared with those before treatment(P＜0.05)，and the above indexes in the observation group were lower than those in the control group (P＜0.05). During treatment，there was no obvious adverse reaction in the two groups. Conclusion：Shentao Ruangan tablets combined with transcatheter arterial chemoembolization for liver cancer can improve the liver function and to some degree inhibit the growth of tumor cells with safe and reliable clinical effect.