四君子汤加味对晚期直肠癌患者免疫功能和生活质量的影响
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R73

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虹口区卫生健康委员会医学科研课题(虹卫1902-04);上海市科学技术课题(19401971600)


Effect of Modified Sijunzi Tang on Immune Function and Quality of Life in Patients with Advanced Rectal Cancer
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    摘要:

    目的:观察四君子汤加味对晚期直肠癌患者免疫功能和生活质量的改善作用。方法:选取晚期直肠癌患者120 例,按随机数字表法分为观察组和对照组各60 例。对照组给予FOLFOX6 方案进行化疗,观察组在对照组基础上给予四君子汤加味治疗。比较2 组近期临床疗效,评价免疫功能和生活质量的变化。结果:观察组近期临床疗效总有效率为65.00%,对照组为30.00%,2 组比较,差异有统计学意义(P<0.05)。2 组治疗前的免疫球蛋白A(IgA)、IgM、IgG 水平比较,差异无统计学意义(P>0.05)。2 组治疗后的IgA、IgM、IgG 水平较治疗前升高(P<0.05),且观察组IgA、IgM、IgG 水平高于对照组(P<0.05)。2 组治疗前的CD4+、CD8+、CD4+/CD8+比较,差异无统计学意义(P>0.05)。2 组治疗后的CD4+、CD8+、CD4+/CD8+较治疗前升高(P<0.05),且观察组CD4+、CD8+、CD4+/CD8+均高于对照组(P<0.05)。2 组治疗前的生活质量评分比较,差异无统计学意义(P>0.05)。2 组治疗后的生活质量评分较治疗前升高(P<0.05),且观察组生活质量评分高于对照组(P<0.05)。结论:四君子汤加味治疗晚期直肠癌患者可以提高近期临床疗效,提升免疫功能,改善患者生活质量。

    Abstract:

    Abstract:Objective:To observe the effect of modified Sijunzi tang on immune function and quality of life in patients with advanced rectal cancer. Methods:A total of 120 cases of patients with advanced rectal cancer were selected and divided into the observation group and the control group according to the random number table method, 60 cases in each group. The control group was given chemotherapy based on FOLFOX6 regimen,and the observation group was additionally treated with modified Sijunzi tang based on the treatment of the control group. The short- term clinical effect in the two groups was compared;the changes of immune function and quality of life were evaluated. Results:The total effective rate of short-term clinical effect was 65.00% in the observation group,higher than that of 30.00% in the control group,the difference being significant(P<0.05). Before treatment, there was no significant difference being found in the comparison of the levels of immunoglobulin A(IgA),IgM and IgG between the two group(P>0.05). After treatment,the levels of IgA,IgM and IgG in the two groups were increased when compared with those before treatment(P<0.05), and the levels in the observation group were higher than those in the control group(P<0.05). Before treatment, there was no significant difference being found in the comparison of CD4+,CD8+ and CD4+/CD8+ between the two groups(P>0.05). After treatment,the indexes of CD4+,CD8+ and CD4+/CD8+ in the two groups were increased when compared with those before treatment(P<0.05),and the above indexes in the observation group were all higher than those in the control group(P<0.05). Before treatment,there was no significant difference being found in the comparison of the scores of quality of life between the two groups(P>0.05). After treatment,the scores of quality of life in the two groups were increased when compared with those before treatment (P<0.05), and the score in the observation group was higher than that in the control group(P<0.05). Conclusion: The application of modified Sijunzi tang for patients with advanced rectal cancer can improve the short- term clinical effect,the immune function,and the quality of life.

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夏晓婷,赵志斌,李芸,陈中怡,余韵诗,钟薏.四君子汤加味对晚期直肠癌患者免疫功能和生活质量的影响[J].新中医,2021,53(3):107-110

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  • 在线发布日期: 2021-02-03
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