Abstract：Objective：To observe the clinical effect of oral administration as well as fumigation and washing with Shujin Zhijing prescription based on routine therapy for spastic hemiplegia after ischemic stroke. Methods：A total of 120 cases of patients with spastic hemiplegia after ischemic stroke were randomly divided into the control group and the observation group，60 cases in each group. Both groups were treated with routine modern medical therapy and rehabilitation technical training；the observation group was additionally treated with oral administration as well as fumigation and washing with Shujin Zhijing prescription. Both groups were treated for six weeks. Before treatment and after six-week treatment，the scores of Modified Ashworth Scale(MAS)，Clinical Spasticity Index(CSI)，Activities of Daily Living(ADL)，National Institutes of Health Stroke Scale(NIHSS) and Fugl- Meyer Assessment(FMA) in the two groups were evaluated. After treatment， the clinical effect in the two groups was compared. Results：After six-week treatment，the clinical effect in the observation group was better than that in the control group(P＜0.05). The scores of MAS，CSI and NIHSS in the two groups were decreased when compared with those before treatment(P＜0.01)，and the above three scores in the observation group were lower than those in the control group(P＜0.01). The ADL scores in the two groups were increased when compared with those before treatment (P＜0.01)， and the score in the observation group was higher than that in the control group(P＜0.01). The scores of upper limbs and lower limbs as well as the total scores in FMA in the two groups were increased when compared with those before treatment(P＜0.01)， and the above three scores in the observation group were higher than those in the control group(P＜ 0.01). Conclusion：Based on routine modern medical treatment，the additional application of oral administration as well as fumigation and washing with Shujin Zhijing prescription for patients with spastic hemiplegia after ischemic stroke can further relieve the degree of spasm，and at the same time improve neurologic impairment，activities of daily living and sports ability with good curative effect.