Abstract： Objective： To observe the nursing effect of Chinese medicine massage manipulation combined with 50% safflower alcohol for prevention of pressure sore in senile bedridden patients. Methods： A total of 86 cases of senile bedridden patients admitted and treated from December，2016 to December，2018 were selected as the study subjects， and were divided into the normal group and the combined nursing group according to random number table method，43 cases in each group. The normal group was given routine nursing，and the combined nursing group was additionally given Chinese medicine massage manipulation combined with 50% safflower alcohol based on routine nursing. The occurrence probability of pressure sore，hospitalization time，and life quality in the two groups were analyzed. Results：The occurrence probability of pressure sore was 6.98% in the combined nursing group，lower than that of 25.58% in the normal group(P＜0.05). The hospitalization time of the combined nursing group was shorter than that in the normal group，the difference being significant (P＜0.05). After nursing， the scores of general health， physiological function， physiological role， body pain， life vitality， social function，emotional role，and mental health in Quality of Life Scale SF-36 in the combined nursing group were higher than those in the normal group(P＜0.05). Conclusion：The nursing of Chinese medicine massage manipulation combined with 50% safflower alcohol for prevention of pressure sore in senile bedridden patients can significantly shorten hospitalization time，and improve life quality.