Abstract： Objective： To observe the effect of Ziyin Qingsang tang combined with Budesonide spray suspension on indexes of the lung function， the proportion of eosinophils(EOS) in whole blood， and sleep quality in children with cough variant asthma(CVA). Methods： A total of 96 cases of CVA children were divided into the control group and the treatment group according to the number table method， 47 and 49 cases in each group respectively. Before treatment， all patients were given anti- infection， fluid replacement， oxygen inhalation， and other routine symptomatic treatments； the control group was given Budesonide spray suspension，and the treatment group was additionally given Ziyin Qingsang tang based on the treatment of the control group. Forced expiratory volume in the first second(FEV1)，forced vital capacity(FVC)，and peak expiratory flow rate(PEFR) were observed and compared between the two groups. The levels of interleukin- 5(IL- 5)， interleukin-10(IL-10)，C-reactive protein(CRP) in serum，and the proportion of eosinophils in induced sputum(EOS%) were observed and compared between the two groups. The scores of cough symptom and the scores of Pittsburgh Sleep Quality Index(PSQI) were observed and compared between the two groups. Results： The total effective rate was 91.84% in the treatment group，and 72.34% in the control group，the difference being significant(P＜0.05). After treatment，the levels of FEV1，FVC，and PEFR in serum in the two groups were significantly higher than those before treatment(P＜0.05)，and each index above in the treatment group was higher than that in the control group(P＜0.05). After treatment，the levels of IL-5 and CRP as well as EOS% in the two groups were lower than those before treatment(P＜0.05)，and the IL-10 level was higher (P＜0.05)；the improvement of each index above in the treatment group was better than that in the control group(P＜0.05). After treatment，the scores of daytime cough，nighttime cough，and PSQI in the two groups were lower than those before treatment(P＜0.05)； each score above in the treatment group was lower than that in the control group(P＜0.05). The total incidence of adverse reactions was 8.16% in the treatment group，and 23.40% in the control group，the difference being significant(P＜0.05). Conclusion： In the treatment of CVA， the therapy of Ziyin Qingsang tang combined with Budesonide spray suspension can effectively recover the lung function，improve inflammatory response of airway and sleep quality，and reduce adverse reactions.