Abstract： Objective： To observe the curative effect of Puji Xiaodu yin combined with prednisone on patients with subacute thyroiditis and its effect on levels of thyrotropin receptor antibody(TRAb) and thyroid peroxidase antibody(TPOAb) in serum. Methods： A total of 75 cases of patients with subacute thyroiditis were selected as the study objects. All patients were divided into the control group and the study group according to the random number table method，37 and 38 cases in each group respectively. The control group was given the oral administration of prednisone tablets，and the study group was additionally given the oral administration of Puji Xiaodu yin based on the treatment of the control group. The clinical effect was evaluated in the two groups. The levels of TRAb and TPOAb in serum were detected. The level of the thyroid function and the recurrence were compared. Results：The total effective rate was 94.74% in the study group，higher than that of 75.68% in the control group(P＜0.05). When compared with those in the same group before treatment，the levels of TRAb，TPOAb， free triiodothyronine(FT3)，and free thyroxine(FT4) in serum in the two groups after treatment were decreased(P＜0.05)；the levels in the study group were lower than those in the control group(P＜0.05). When compared with those in the same group before treatment，the levels of thyroid stimulating hormone(TSH) in the two groups after treatment were increased(P＜0.05)； the level in the study group was higher than that in the control group(P＜0.05). The follow-up was conducted after six-month drug withdrawal. During the follow-up，the recurrence rate was 5.00% in the study group，lower than that of 40.00% in the control group(P＜0.05). Conclusion：In the treatment of subacute thyroiditis，the therapy of Puji Xiaodu yin combined with prednisone can improve general curative effect，reduce the recurrence rate，and conduce to improving the thyroid function.