温针疗法联合追风透骨胶囊治疗膝骨关节炎临床研究
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R684.3;R246

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Clinical Study on Warm Needling Therapy Combined with Zhuifeng Tougu Capsules for Knee Osteoarthritis
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    摘要:

    目的:观察在常规西药治疗的基础上联合温针疗法、追风透骨胶囊治疗膝骨关节炎(KOA) 的临床疗效。方法:将80 例KOA 患者按照随机数字表法分为对照组和观察组各40 例,对照组给予塞来昔布胶囊治疗,观察组在对照组的基础上联合温针疗法、追风透骨胶囊治疗。治疗30 d 后,观察比较2 组临床疗效,2 组治疗前后的症状积分、膝关节功能、疼痛程度[视觉模拟评分法(VAS) 评分]、炎症因子[肿瘤坏死因子-α(TNF-α)、基质金属蛋白酶-1(MMP-1)、基质金属蛋白酶-3(MMP-3)、白细胞介素-2(IL-2)] 水平变化;随访1 个月,对2 组症状积分、膝关节功能、疼痛程度进行追踪观察。结果:观察组总有效率为90.0%,对照组为75.0%,2 组比较,差异有统计学意义(P<0.05)。治疗前,2 组症状积分、VAS 评分比较,差异无统计学意义(P>0.05);治疗后,2 组症状积分、VAS 评分均较治疗前降低(P<0.05),且观察组2 项评分均低于对照组(P<0.05);治疗后随访1 个月,2 组症状积分、VAS 评分仍低于治疗前(P<0.05),且观察组2 项评分均低于对照组(P<0.05)。治疗前,2 组膝关节运动功能评分比较,差异无统计学意义(P>0.05);治疗后,2 组膝关节运动功能评分均较治疗前升高(P<0.05),且观察组评分高于对照组(P<0.05);治疗后随访1 个月,2 组膝关节运动功能评分仍高于治疗前(P<0.05),且观察组评分高于对照组(P<0.05)。治疗前,2 组炎症因子TNF-α、MMP-1、MMP-3、IL-2 水平比较,差异无统计学意义(P>0.05);治疗后,2 组各炎症因子水平均较治疗前降低(P<0.05),且观察组各项指标均低于对照组(P<0.05)。结论:温针疗法联合追风透骨胶囊治疗KOA 能显著提高疗效,改善症状,缓解疼痛,恢复膝关节功能,降低血清炎症因子水平。

    Abstract:

    Abstract: Objective: To observe the clinical effect of warm needling therapy combined with Zhuifeng Tougu capsules based on routine western medicine for knee osteoarthritis(KOA). Methods:A total of 80 cases of KOA patients were divided into the control group and the observation group according to the random number table method,40 cases in each group. The control group was treated with celecoxib capsules and the observation group was additionally treated with warm needling therapy combined with Zhuifeng Tougu capsules based on the treatment in the control group. After 30- day treatment,the clinical effect in the two groups was observed and compared. Before and after treatment,the changes in symptom scores, knee joint function,pain degree of Visual Analogue Scale(VAS) scores and levels of inflammatory factors in the two groups were observed and compared. The symptom scores,knee joint function and pain degree in the two groups were followed up for one month. Results:The total effective rate was 90.0% in the observation group and 75.0% in the control group,the difference being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of scores of symptoms and VAS between the two groups(P>0.05). After treatment,the scores of symptoms and VAS in the two groups were decreased when compared with those before treatment(P<0.05), and the above two scores in the observation group were lower than those in the control group(P<0.05); after one- month follow- up, the scores of symptoms and VAS in the two groups were lower than those before treatment(P<0.05),and the above two scores in the observation group were lower than those in the control group(P<0.05). Before treatment,there was no significant difference being found in the comparison of motor function scores in knee joint between the two groups(P>0.05). After treatment,the motor function scores in knee joint in the two groups were increased when compared with those treatment(P<0.05),and the score in the observation group was higher than that in the control group(P<0.05); one month after treatment, the motor function scores in knee joint in the two groups were higher than those before treatment(P<0.05), and the score in the observation group was higher than that in the control group(P<0.05). Before treatment,there was no significant difference being found in the comparison of levels of inflammatory factors including tumor necrosis factor- α(TNF- α), matrix metalloproteinase- 1(MMP- 1),matrix metalloproteinase- 3(MMP- 3) and interleukin- 2(IL- 2) between the two groups(P> 0.05). After treatment, the levels of inflammatory factors in the two groups were decreased when compared with those before treatment(P<0.05),and the above indexes in the observation group were lower than those in the control group(P< 0.05). Conclusion:Warm needling therapy combined with Zhuifeng Tougu capsules for KOA can improve curative effect and symptoms,relieve pain,restore knee joint function,and reduce the levels of inflammatory factors in synovial fluid.

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徐守臣,徐笑,刘晓婉.温针疗法联合追风透骨胶囊治疗膝骨关节炎临床研究[J].新中医,2021,53(10):101-105

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  • 在线发布日期: 2021-05-24
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