Abstract： Objective： To observe the effect of Niaoduqing granules combined with valsartan on kidney function， inflammatory factors and immune function in patients with early diabetic nephropathy(DN). Methods：A total of 87 cases of patients with early DN were divided into the observation group and the control group according to the random number table method， 44 and 43 cases in each group respectively. The control group was treated with valsartan， and the observation group was treated with Niaoduqing granules combined with valsartan. Both groups were treated for three months. The levels of kidney function indexes， inflammatory factors and immune function indexes before and after treatment as well as the clinical effect in the two groups were compared，and the incidences of adverse reactions in the two groups were recorded. Results：The total effective rate was 95.45% in the observation group，higher than that of 81.40% in the control group(P＜ 0.05). After treatment， the levels of 24- hour urinary protein， serum creatinine(SCr)， blood urea nitrogen(BUN)， urinary albumin excretion rate(UAER)，24- hour urine red blood cell count，tumor necrosis factor- α(TNF- α)，interleukin- 6(IL- 6)， interleukin-8(IL-8)，interleukin-18(IL-18)，intercellular adhesion molecule-1(ICAM-1) and β2-microglobulin(β2-MG) in the observation group were lower than those in the control group(P＜0.01)，and the levels of CD3+ and CD4+/CD8+ were higher(P＜0.01). The incidence of adverse reactions was 15.91% in the observation group and 11.63% in the control group， there being no significant difference(P＞0.05). Conclusion：Niaoduqing granules combined with valsartan for early DN patients can effectively improve kidney function，reduce levels of inflammatory factors in serum，and promote immune function with good medication safety.