Abstract：Objective：To observe the effect of compound Biejia Ruangan tablets combined with entecavir for hepatitis B cirrhosis. Methods：A total of 210 cases of patients with hepatitis B cirrhosis were divided into two groups according to the random number table method，105 cases in each group. Both groups were intervened with comprehensive nursing；the control group was additionally treated with entecavir， and the observation group was additionally treated with compound Biejia Ruangan tablets combined with entecavir. Before and after treatment， the changes in the liver function indexes including aspartate aminotransferase(AST)， alanine aminotransferase(ALT)， total bilirubin(TBil) and prothrombin activity (PTA)，the liver fibrosis indexes including hyaluronic acid(HA)，laminin(LN)，type Ⅳ collagen(Ⅳ-C) and procollagen type Ⅲ (PC-Ⅲ)，as well as the positive rates of hepatitis B e-antigen(HBeAg) and hepatitis B e-antibody(HBeAb)，and the levels of hepatitis B virus deoxyribonucleic acid(HBV- DNA) in the two groups were observed and compared. Results： After treatment， the levels of AST， ALT and TBIL in the two groups were significantly decreased when compared with those before treatment(P＜0.05)， and the PTA levels were increased(P＜0.05)； the improvement of the above indexes in the observation group was more significant than that in the control group(P＜0.05). After treatment， the levels of HA， LN， Ⅳ-C，PC-Ⅲ and HBV-DNA in the two groups were significantly decreased when compared with those before treatment(P＜ 0.05)，and the above indexes in the observation group were lower than those in the control group(P＜0.05). After treatment， the positive rate of HBeAg in the observation group was decreased when compared with that in the control group，and the positive rate of HBeAb was increased，differences being significant(P＜0.05). Conclusion：Compound Biejia Ruangan tablets combined with entecavir for hepatitis B cirrhosis can effectively improve levels of liver function and liver fibrosis indexes，regulate the positive expressions of HBeAg and HBeAb in the body，and can significantly down- regulate the levels of HBV-DNA.