Abstract： Objective： To observe the effect of emotional nursing of Chinese medicine combined with positive reinforcement intervention model on compliance of intravenous infusion and pain degree of hospitalized children. Methods：A total of 160 hospitalized children with intravenous infusion were randomly divided into the control group and the observation group，80 cases in each group. The control group was given emotional nursing of Chinese medicine. The observation group was additionally given nursing with positive reinforcement intervention model on the basis of the control group. The compliance， the rate of successful puncture， satisfaction， medicine leakage rate， medicine withdrawal rate and needle dropout were observed and compared between the two groups. The Wong-Baker Faces Pain Rating Scale(Wong-Baker) and modified FLACC Pain Scale(FLACC) were applied to observing the degree of pain，and the scores were compared between the two groups. Results：The successful rate at the first attempt of puncture，good compliance rate and parent satisfaction rate were 93.75%，96.25% and 91.25% in the observation group，and 76.25%，81.25% and 78.75% in the control group， respectively，differences being significant(P＜0.05). Wong- Baker scores and FLACC pain scores for evaluating the rate of mild pain were 65.00% and 62.50% in the observation group，and 42.50% and 41.25% in the control group，respectively， differences being significant(P＜0.05). After infusion， the medicine leakage rate， the medicine withdrawal rate and the needle dropout rate were 2.50%，5.00% and 1.25% in the observation group，and 11.25%，16.25% and 8.75% in the control group， respectively， differences being significant(P＜0.05). Conclusion： For children undergoing intravenous infusion，emotional nursing of Chinese medicine combined with nursing with positive reinforcement intervention model has significant nursing effect，which helps obtain a higher rate of successful puncture，compliance，and satisfaction，and lower rates of medicine leakage，medicine withdrawal，and needle dropout；children will not suffer a lot from pain.