Abstract： Objective： To observe the clinical value and nursing effect of alprostadil combined with salvia injection for lower extremity deep venous thrombosis(DVT) in senile patients with hip fracture. Methods：A total of 84 cases of senile patients with hip fracture were divided into the control group and the observation group according to the random number table method， 42 cases in each group. After operation， the control group was given subcutaneous injection of low molecular weight heparin for two weeks，and the observation group was given intravenous infusion of alprostadil injection combined with salvia injection for two weeks. The differences in DVT incidences， 48- hour wound drainage， 10 cm infrapatellar circumferences before and after treatment， Visual Analogue Scale(VAS) scores， platelets， activated partial thromboplastin time(APTT)， and D-dimer(D-D) between the two groups were compared. Results：The incidence of DVT in the observation group was lower than that in the control group，and the 48-hour wound drainage was less，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the 10 cm infrapatellar circumferences and VAS scores between the two groups(P＞0.05). After treatment， the 10 cm infrapatellar circumferences and VAS scores in the two groups were improved when compared with those before treatment；the 10 cm infrapatellar circumference in the observation group was shorter than that in the control group， and the VAS score was lower，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of platelets，APTT and D-D between the two groups(P＞0.05). After treatment，platelets，APTT and D-D in the two groups were improved when compared with those before treatment；the platelet count in the observation group was fewer than that in the control group，APTT was shorter，and D- D was lower，the difference being significant(P＜0.05). Conclusion： The application of alprostadil combined with salvia injection for DVT in senile patients with hip fracture can significantly reduce the incidence of lower extremity DVT and relieve the pain of patients.