Abstract：Objective：To observe the clinical effect of the therapy of Chinese medicine comprehensive nursing combined with swallowing training on the intervention of swallowing dysfunction(SD) after stroke. Methods：A total of 86 SD patients after stroke were selected and divided into the control group and the observation group according to the random number table method，43 cases in each group. The control group was given swallowing training treatment，and the observation group was additionally given Chinese medicine comprehensive nursing based on the treatment of the control group. The two groups were intervened for four weeks. The improvement of swallowing function and quality of life，and the incidence of complications were compared between the two groups. Results：After intervention，the total effective rate was 93.02% in the observation group and 76.74% in the control group，the difference being significant(P＜0.05). After intervention，the scores of Chinese version of Gugging Swallowing Screen(GUSS) in both groups were increased when compared with those before intervention (P＜0.05)，and the scores of Standardized Swallowing Assessment(SSA) were decreased when compared with those before intervention(P＜0.05). The GUSS score in the observation group was higher than that in the control group(P＜0.05)，and SSA score was lower than that in the control group(P＜0.05). The total incidence of complications was 4.65% in the observation group and 18.60% in the control group ， the difference being significant(P ＜ 0.05). After intervention ， the scores of the Stroke- Specific Quality of Life(SS- QOL) and the Swallowing- Quality of Life(SWAL- QOL) in the two groups were all increased when compared with those before intervention(P ＜ 0.05). The scores of SS-QOL and SWAL-QOL in the observation group were higher than those in the control group(P＜0.05). Conclusion： The therapy of Chinese medicine comprehensive nursing combined with swallowing training can effectively improve the swallowing function of SD patients after stroke，reduce the incidence of complications，and improve their quality of life.