参芪归芍汤治疗复发性流产临床研究
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R714.2

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河南省2018科技发展计划项目(182102310140)


Clinical Study on Shenqi Guishao Tang for Recurrent Spontaneous Abortion
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    摘要:

    目的:观察参芪归芍汤治疗复发性流产的临床疗效。方法:选择复发性流产患者 120 例,按随机数字表法分为对照组和研究组各 60 例。对照组给予低分子肝素钙治疗,研究组给予参芪归芍汤治疗。比较 2 组输卵管通畅率、再次流产率、宫内妊娠成功率、不良反应发生率,统计分析中医证候积分、激素水平。结果:治疗后,研究组输卵管通畅率和宫内妊娠成功率均高于对照组,再次流产率低于对照组,差异均有统计学意义 (P<0.05)。治疗前,2 组中医证候积分比较,差异无统计学意义(P>0.05)。治疗后,2 组中医证候积分均低于治疗前,且研究组中医证候积分低于对照组,差异均有统计学意义(P<0.05)。治疗前,2 组血清卵泡刺激素(FSH)、黄体生成激素(LH)、孕激素(P)及雌二醇(E2)水平比较,差异均无统计学意义(P>0.05)。治疗后,2 组 FSH、LH、P、E2水平均高于治疗前 (P<0.05),且研究组 FSH、LH、P、E2水平均高于对照组 (P<0.05)。研究组不良反应发生率为 3.4%,低于对照组 20.0%,差异有统计学意义(P<0.05)。结论:参芪归芍汤治疗复发性流产疗效显著,能够提高宫内妊娠成功率,降低不良反应发生,缓解受孕之后先兆流产临床症状。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Shenqi Guishao tang for recurrent spontaneous abortion. Methods: A total of 120 cases of patients with recurrent spontaneous abortion were selected and divided into the control group and the study group according to the random number table method,60 cases in each group. The control group was treated with low molecular weight heparin calcium,and the study group was treated with Shenqi Guishao tang. The tubal patent rate,the rate of repeated abortion,the success rate of intrauterine pregnancy and the incidence of adverse reactions in the two groups were compared; Chinese medicine syndrome scores and hormone levels were counted and analyzed. Results: After treatment,the tubal patent rate and the success rate of intrauterine pregnancy in the study group were higher than those in the control group,and the rate of repeated abortion was lower,differences being significant(P<0.05). Before treatment, there was no significant difference being found in the comparison of Chinese medicine syndrome scores between the two groups(P>0.05). After treatment, Chinese medicine syndrome scores in the two groups were lower than those before treatment,and the score in the study group was lower than that in the control group,differences being significant(P<0.05). Before treatment, there was no significant difference being found in the comparison of the levels of follicle stimulating hormone(FSH),luteinizing hormone(LH),progesterone(P) and estradiol(E2) in serum between the two groups(P>0.05). After treatment,the levels of FSH,LH,P and E2 in the two groups were all higher than those before treatment(P<0.05),and the levels in the study group were higher than those in the control group(P<0.05). The incidence of adverse reactions was 3.4% in the study group,lower than that of 20.0% in the control group,the difference being significant(P<0.05). Conclusion:The application of Shenqi Guishao tang has significant curative effect in treating recurrent spontaneous abortion, which can improve the success rate of intrauterine pregnancy, reduce the incidence of adverse reactions, and relieve the clinical symptoms of threatened abortion after conception.

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苏敏,胡颜霞,姜秋慧,姚丽.参芪归芍汤治疗复发性流产临床研究[J].新中医,2021,53(1):90-93

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  • 在线发布日期: 2021-01-11
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