Abstract：Objective：To observe the clinical effect of the therapy of Bushen Huoxue prescription combined with low molecular weight heparin on recurrent spontaneous abortion complicated with abnormal uterine artery blood flow. Methods： A total of 72 patients with recurrent spontaneous abortion complicated with increased uterine artery blood flow resistance were selected and divided into the observation group and the control group according to the random number table method， 36 cases in each group. The control group was treated with low molecular weight heparin，and the observation group was additionally treated with Bushen Huoxue prescription based on the treatment of the control group. The clinical effect，Chinese medicine syndrome scores ， resistance index of uterine artery(RI) ， peak systolic velocity/end diastolic(S/D) ， levels of β -human chorionic gonadotropin in serum(β-HCG)，estradiol(E2) and progesterone(P)，and success rate of fetal protection at 12 weeks were compared between the two groups. Results：The total effective rate was 86.11% in the observation group and 69.44% in the control group，the difference being significant(P＜0.05). After treatment，the Chinese medicine syndrome scores in both groups were decreased when compared with those before treatment(P＜0.05)， and the scores in the observation group were lower than those in the control group(P＜0.05). The left RI and right RI and S/D levels in both groups were significantly decreased when compared with those before treatment(P＜0.05)， and the above two levels in the observation group were lower than those in the control group(P＜0.05). After treatment，the levels of β-HCG，P and E2 in serum in the two groups were increased when compared with those before treatment(P＜0.05)，and the levels of β-HCG and P in serum in the observation group were higher than those in the control group(P＜0.05)， while the E2 level was not significantly correlated with the control group(P＞0.05). After treatment，the success rate of fetal protection at 12 weeks and the rate of repeat abortion were 88.89% and 11.11% in the observation group，and 72.22% and 27.78% in the control group， respectively，the difference being significant(P＜0.05). Conclusion：The therapy of Bushen Huoxue prescription combined with low molecular weight heparin can effectively reduce the uterine artery blood flow resistance in patients with recurrent spontaneous abortion，improve the blood circulation between mother and fetus，and help to maintain the normal pregnancy.