Abstract： Based on the coastal location and humid climate of Wenzhou， the authors expounded the etiology， pathogenesis，syndrome differentiation typing，principles，methods，prescriptions and medicine of Corona Virus Disease 2019(COVID- 19) from the perspective of Chinese medicine， and analyzed one case. The COVID- 19 in this area can be classified as a disease of pestilence and a damp epidemic in Chinese medicine. The location of it is in the lung， and it damages the heart，liver，stomach and intestines. The main pathogenesis of COVID-19 is mixed cold，heat，damp and toxin， but its fundamental is the transformation into heat and the damage to fluid. In early stage， a large dose of heatclearing and detoxifying Chinese herbs should be applied to terminate its tendency of heat and transmutation. For patients with syndrome of dampness- toxin in the lung in early stage，modified Huoxiang Zhengqi powder combined with Yinqiao powder should be prescribed. For patients with syndrome of epidemic toxin obstructing the lung in middle stage，modified Maxing Shigan tang combined with Xiaoxianxiong tang and Weijing tang should be applied. For patients with syndrome of dual blaze of qi- blood aspects in middle stage，modified Qingwen Baidu powder should be used. For critically ill patients with syndrome of internal block and external collapse，modified Shenfu tang or Shengmai powder should be adopted. For patients with syndrome of dual deficiency of the lung- spleen in convalescence stage，modified Shenling Baizhu powder and Bufei tang should be employed. In conclusion，the integrated Chinese and western medicine therapy has significant therapeutic effect in treating therapy COVID-19 based on the considerations of person and place in diagnosis and treatment，and through syndrome differentiation and treatment.