Abstract： Objective： To observe the clinical effect of Shendi granules combined with Huangkui capsules for chronic glomerulonephritis and its effect on the levels of serum inflammatory factors，urinary podocalyxin(PCX) and B7-1. Methods： A total of 70 cases of patients with chronic glomerulonephritis were randomly divided into the observation group and the control group，35 cases in each group. Both groups were given standardized western medicine treatment；the control group was additionally treated with Huangkui capsules，and the observation group was additionally treated with Shendi granules combined with Huangkui capsules. The clinical effect，24 h urine protein excretion(24 hUTP) as well as the levels of serum inflammatory factors，urinary PCX and B7-1 in the two groups were compared. Results：The curative effect of medication in the observation group was significantly higher than that in the control group(P＜0.05). After treatment，the levels of 24 hUTP and IL-2 and IL-17 in serum in the two groups were decreased when compared with those before treatment(P＜0.05)，and the levels of IL- 4 were increased(P＜0.05)， and the comparison between the two groups showed significance in the difference(P＜0.05). After treatment，the levels of urinary PCX and B7-1 in the two groups were decreased when compared with those before treatment(P＜0.05)，and the comparison between the two groups showed significance in the difference(P＜ 0.05). Conclusion：The therapy of Shendi granules combined with Huangkui capsules has definite curative effect in treating chronic glomerulonephritis，which can significantly enhance the clinical effect，improve the kidney function，and regulate the levels of inflammatory factors，PCX and B7-1.