Abstract：Objective：To observe the therapeutic effect of Angong Niuhuang Pills combined with western medicine on patients with cerebral hemorrhage after operation. Methods：200 cases of cerebral hemorrhage patients were selected as the research objects，and they were divided into 2 groups (100 cases each) by random number table method. Both groups were treated with brain surgery after admission， the control group was treated with conventional western medicine after operation， and the observation group was treated with Angong Niuhuang pills on the basis of the control group after operation. The clinical efficacy， the scores of Traditional Chinese Medicine(TCM) syndrome and National Institute of the Health Stroke Scale(NIHSS) after treatment were compared between the two groups，as well as Modified Barthel Index(MBI) score and oxidative stress index. Results：After treatment，the total clinical effective rate of the observation group(92.00%) was better than that of the control group(65.00%) (P＜0.05)；after treatment，the scores of TCM syndromes and NIHSS in the two groups were lower than those before treatment(P＜0.05). The scores of TCM syndromes and NIHSS of the observation group were lower than those of the control group(P<0.05)；the MBI scores of the two groups were higher than those before treatment(P<0.05)，and the MBI scores in the observation group were higher than those in the control group(P< 0.05). After treatment， the levels of serum superoxide dismutase(SOD)， glutathione peroxidase(GSH- Px)， and total antioxidant capacity(TAC) in the two groups were higher than those before treatment(P＜0.05). The level of malondialdehyde (MDA) was lower than that before treatment(P＜0.05)；the serum SOD，GSH-Px and TAC levels of the observation group were higher than those in the control group(P＜0.05)，and the serum MDA level was lower than that in the control group(P＜ 0.05). Conclusion： After intracerebral hemorrhage， Angong Niuhuang Pills combined with western medicine has a satisfactory therapeutic effect，which can effectively relieve symptoms，reduce nerve damage，improve daily life self-care ability，and have obvious anti-oxidative stress effects.