Abstract：Objective：To observe the clinical effect of gastrodin injection combined with atorvastain calcium tablets for acute cerebral hemorrhage and the effect on the levels of endothelin-1(ET) and procalitonin(PCT) in serum. Methods：A total of 68 cases of patients with acute cerebral hemorrhage were selected and divided into the control group and the observation group according to the random number table method，34 cases in each group. The control group was treated with atorvastain calcium tablets，and the observation group was additionally treated with gastrodin injection based on the treatment of the control group. Both groups were continuously treated for two weeks. The scores of Glasgow Coma Scale(GCS) and National Institutes of Health Stroke Scale(NIHSS)，clinical effect，and the levels of ET-1 and PCT in serum were compared between the two groups. Results：The total effective rate was 94.12% in the observation group，and 70.59% in the control group， the difference being significant(P＜0.05). After treatment，the scores of GCS in the two groups were significantly increased (P＜0.05)， and NIHSS scores were significantly decreased when compared with those before treatment(P＜0.05)； the improvement of the two scores in the observation group was more significant than that in the control group(P＜0.05). After treatment，the levels of ET-1 and PCT in serum in the two groups were significantly lower than those before treatment(P＜ 0.05)，and the two levels in the observation group were lower than those in the control group(P＜0.05). Conclusion：The therapy of astrodin injection combined with atorvastain calcium tablets has defined curative effect on treatment of acute cerebral hemorrhage，which can effectively reduce the levels of ET and PCT in serum.