Abstract：Objective：To explore the clinical effect of Tongqiao Huoxue tang combined with acupuncture in the treatment of qi stagnation and blood stasis syndrome in Alzheimer disease(AD). Methods：A total of 92 AD patients with qi stagnation and blood stasis syndrome were selected and divided into 2 groups according to the random number table method，each with 46 cases. The observation group was given Tongqiao Huoxue tang combined with acupuncture treatment，and the control group only took acupuncture treatment. After treatment，the clinical efficacy，TCM syndrome score，Mini- mental State Examination(MMSE) score and serum homocysteine(Hcy) levels were compared between the two groups. Results：The total effective rate of the observation group(84.78%) was better than that of the control group(67.39%)(P＜0.05). The scores of TCM syndromes and serum Hcy levels in the two groups were lower than those before treatment(P＜0.05). The scores of TCM syndromes and serum Hcy levels in the observation group were lower than those in the control group(P＜0.05)；the language ability of the two groups after treatment，memory，the scores of computing power and attention，and orientation were all higher than those before treatment(P＜0.05)，and the above-mentioned MMSE detailed scores in the observation group were higher than those in the control group(P＜0.05). Conclusion：For AD patients with qi stagnation and blood stasis syndrome， Tongqiao Huoxue tang combined with acupuncture has a significant therapeutic effect， can significantly alleviating clinical symptoms，improving cognitive function，and reducing serum Hcy levels.