Abstract：Objective：To explore the effect of Chinese herbal fumigation combined with point application on quality of life of patients with depression. Methods：A total of 175 cases of patients with depression were divided into the control group and the observation group according to the random number table method，87 and 88 cases in each group respectively. The control group was treated with Chinese herbal decoction， and the observation group was additionally treated with Chinese herbal fumigation combined with point application based on the treatment of the control group. The changes in the scores of anxiety and depression，sleep quality and quality of life before and after treatment in the two groups were compared. Results：After treatment，the scores of Hamilton Depression Scale of 17 Items(HAMD- 17) and Hamilton Anxiety Scale(HAMA) in the two groups were improved when compared with those before treatment(P＜0.05)； the above scores in the observation group were better than those in the control group，the difference being significant(P＜0.05). After treatment，the scores of sleep quality in the two groups were improved when compared with those before treatment(P＜0.05)， and the score in the observation group was better than that in the control group，the difference being significant(P＜0.05). After treatment，the scores of mental health， emotional function， psychological state， physiological function， activity ability， social function， body pain and overall health in the observation group were significantly better than those in the control group，the difference being significant(P＜0.05). Conclusion：The therapy of Chinese herbal fumigation combined with point application for patients with depression can effectively relieve their anxiety and depression，and improve sleep quality and quality of life.