Abstract： Objective： To observe the clinical effect of Xiaotong plaster combined with moxibustion for scapulohumeral periarthritis. Methods： A total of 98 cases of patients with scapulohumeral periarthritis of cold- dampness obstruction type who met requirements were randomly divided into the control group and the observation group，49 cases in each group. The control group was given the oral administration of meloxicam tablets， and irradiation by specific electromagnetic wave therapeutic apparatus；after irradiation，indometacin cataplasm was applied to shoulder joint in the affected side；the control group was continuously treated for three weeks. The observation group was given the external application of Xiaotong plaster combined with moxibustion，and treated for three weeks. Both groups were given comprehensive nursing measures，such as psychological nursing， guidance of daily life and functional exercise， and nursing guidance of therapeutic measures. Before and after treatment，the degree of pain in shoulder joint was evaluated via Visual Analogue Scale(VAS)；the function of shoulder joint was evaluated via Constant-Murley shoulder scoring system；activity of daily living was evaluated via Barthel Index(BI) scoring scale. The incidence of skin irritative reaction during treatment was recorded， and the clinical effect was compared between the two groups. Results： After treatment， the clinical effect in the observation group was better than that in the control group(P＜0.05). In the two groups， the scores of pain evaluated by Constant- Murley shoulder scoring system， activity of daily living， range of motion and muscle strength， as well as the total scores were increased when compared with those before treatment(P＜0.01)；the above four scores and the total score in the observation group were all higher than those in the control group(P＜0.01). The scores of VAS and BI in the two groups were decreased when compared with those before treatment(P＜0.01)，and the two scores in the observation group were lower than those in the control group (P＜0.01). There was no significant difference being found in the incidence of skin irritative reaction in the two groups(P＞0.05). Conclusion：The application of Xiaotong plaster combined with moxibustion in treating scapulohumeral periarthritis with cold-dampness obstruction syndrome，can significantly reduce pain in the affected part，improve physical function of knee joint，and promote patients' activity of daily living，with significant clinical effect.