Abstract：Objective：To observe the effect of five notes therapy of Chinese medicine assisted drugs to achieve analgesia in improving moderate or severe cancer pain. Methods：A total of 60 cases of patients with middle and terminal cancer and moderate or severe cancer pain were collected and randomly divided into two groups，30 cases in each group. The control group was given the corresponding dose of oxycodone hydrochloride sustained-release tablets and other drugs for analgesia according to their pain degree by World Health Organization(WHO) three- step analgesic ladder，and the observation group was additionally treated with five notes therapy of Chinese medicine based on the treatment of the control group. After treatment for 72 hours， the pain scores， anxiety and changes in heart rate and respiratory rate in the two groups were observed. Results： After treatment for 72 hours， the scores of Numerical Rating Scale(NRS) and Hamilton Anxiety Scale (HAMA) in the observation group were significantly lower than those in the control group，differences being significant(P＜ 0.05)；the heart rate and respiratory rate in the two groups were decreased when compared with those before treatment and returned to normal range， but there being no significance in the difference(P＞0.05). Conclusion： Five notes therapy of Chinese medicine can effectively assist drugs to achieve analgesia，regulate anxiety due to cancer pain，and play a stable role in vital signs such as heart rate and respiratory rate.