Abstract：Objective：To observe the clinical effect of the therapy of bath with compound Huangbai lotion combined with alginate dressing on promoting wound healing of patients after undergoing surgery for high perianal abscess. Methods：A total of 82 patients who underwent surgery for high perianal abscess were randomly divided into the control group and the combination group according to the proportion of sealed envelope method，41 cases in each group. Patients in the control group were treated with alginate dressing after the surgery，and patients in the combination group additionally bathed with compound phellodendrine lotion based on the treatment of the control group. The wound healing in the two groups were compared，including changes in wound healing time，dressing change times，score of wound drainage amount，score of wound edema， wound pain degree and pH value. Results： The total effective rate of wound healing was 97.56% in the combination group and 78.05% in the control group，the difference being significant(P＜0.05). After treatment，the wound healing time in the combination group was shorter than that in the control group，and the dressing change times，score of wound drainage amount as well as score of wound edema were lower than those in the control group， differences being significant(P＜0.05). Scores of wound pain in the two groups were decreased successively on the third， seventh and fourteenth day after the surgery； compared with the previous time point， differences were significant(P＜0.05)， and the score of pain at each time point in the combination group was lower than that in the control group(P＜0.05). On the 14th day after the surgery，the pH values in the two groups were significantly decreased when compared with those on the third day after the surgery(P＜0.05)， and the pH value in the combination group was lower than that in the control group(P＜0.05). Conclusion：The therapy of bath with compound Huangbai lotion combined with alginate dressing can promote wound healing of patients after undergoing surgery for high perianal abscess， which can improve the symptoms and signs of wound drainage，edema and pain，reduce the pH value of wound.