Abstract： Objective： To observe the clinical effect of Yishen Xiezhuo tang combined with western medicine and hemodialysis for uremia. Methods：A total of 100 cases of patients with uremia were selected and divided into the control group and the observation group according to the random number table method，50 cases in each group. The control group was given western medicine and hemodialysis，and the observation group was additionally treated with Yishen Xiezhuo tang based on the treatment of the control group. Both groups were continuously treated for four weeks. The symptom scores， clinical effect，the kidney function indexes and nutritional indexes were compared between the two groups. Results：After treatment， the scores of dim complexion， lassitude and lack of strength， lack of appetite and torpid intake， as well as sloppy stool and edema in the observation group were all lower than those in the control group(P＜0.05). The total effective rate was 96.00% in the observation group，higher than that of 84.00% in the control group(P＜0.05). After treatment，the levels of blood urea nitrogen(BUN)，serum creatinine(SCr) and 24 h urine protein quantification in the observation group were lower than those in the control group(P＜0.05)， and the level of creatinine clearance rate(CCr) was higher than that in the control group(P＜0.05). After treatment， the levels of albumin， prealbumin， transferrin and hemoglobin in serum in the observation groups were higher than those in the control group(P＜0.05). Conclusion： The therapy of Yishen Xiezhuo tang combined with western medicine and hemodialysis in treating uremia， can effectively improve the clinical symptoms， the kidney function and nutritional status.