Abstract： Objective： To observe the clinical effect of Xiaoqinglong tang combined with azithromycin for infantile pneumonia and its effect on T lymphocyte subsets. Methods：A total of 86 cases of children with pneumonia were randomly divided into two groups. The control group was treated with azithromycin，and the study group was additionally treated with Xiaoqinglong tang based on the treatment of the control group. The levels of inflammatory factors and T lymphocyte subsets， immune function and curative effect in the two groups were compared. Results：Before treatment，there was no significant difference in the comparison of the indexes of inflammatory factors between the two groups(P＞0.05). After treatment，the levels of inflammatory factors in the study group were lower than those in the control group(P＜0.05). Before treatment， there was no significant difference in the comparison of the levels of T lymphocyte subsets between the two groups(P＞0.05). After treatment，the levels of T lymphocyte subsets in the study group were better than those in the control group(P＜0.05). Before treatment，there was no significant difference in the comparison of the indexes of immune function between the two groups(P＞0.05). After treatment，the levels of IgG，IgA and IgM in the study group were higher than those in the control group(P＜0.05). The curative effect in the study group was better than that in the control group(P＜0.05). Conclusion： The application of Xiaoqinglong tang combined with azithromycin for children with pneumonia has high safety and significant effect，which can effectively reduce the levels of inflammatory factors and T lymphocyte subsets，and improve their immune function as well as clinical symptoms.