Abstract：Objective：To study the effect of nursing and herbal enema on patients with gastrointestinal dysfunction in intensive care unit(ICU). Methods：A total of 82 cases of ICU patients with gastrointestinal dysfunction were selected as the observation objects， and divided into the study group and the experiment group according to the random number table method， 41 cases in each group. All patients were treated with herbal enema； the control group was additionally given routine nursing，and the experiment group was given comfortable nursing. The inflammatory factors，the clinical indexes and the complications in the two groups were compared. Results：Before intervention，there was no significant difference being found in the comparison of the levels of CRP，IL-6 and TNF-α between the two groups(P＞0.05). After intervention，the inflammatory indexes in the two groups were improved when compared with those before nursing，and the levels of CRP， IL-6 and TNF-α in the experiment group were lower than those in the control group，the difference being significant(P＜ 0.05). The defecation time， the anus exhaust time and the recovery time of bowel sound in the experiment group were shorter than those in the control group(P＜0.05). The incidence of complications was 7.32% in the experiment group and 31.71% in the control group，the difference being significant(P＜0.05). Conclusion：The intervention of comfortable nursing for patients with gastrointestinal dysfunction in ICU treated with herbal enema can improve the inflammatory reaction， shorten the recovery time，and is not easy to have complications.