Abstract：Objective：To study the effect of Shenqi Fuzheng tang on the immune function，the levels of cytokines and the quality of life in patients with gastric cancer in stage III to IV. Methods：A total of 86 cases of patients with gastric cancer in stage III to IV were selected and divided into the control group and the observation group according to the random number table method，43 cases in each group. The control group was treated with XELOX chemotherapy and the observation group was additionally treated with Shenqi Fuzheng tang based on the treatment of the control group. Before and after treatment， the immune function，the levels of cytokines，the quality of life and the incidence of chemotherapeutic toxic reactions in the two groups were compared. Results：Before treatment，there was no significant difference being found in the comparison of CD3+，CD4+，CD8+ and CD4+/CD8+ between the two groups(P＞0.05). After treatment，CD3+，CD4+ and CD4+/CD8+ in the observation group were higher than those before treatment and those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of soluble interleukin- 2 receptor(SIL- 2R)， interleukin-6(IL-6) and tumor necrosis factor α(TNF-α) between the two groups(P＞0.05). After treatment，the levels of SIL-2R，IL-6 and TNF-α in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above levels in the observation group were lower than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the scores of Quality of Life Scale(QOL) between the two groups (P＞0.05). After treatment，the QOL score in the observation group was higher than that before treatment and that in the control group(P＜0.05)，and the QOL score in the control group was lower than that before treatment(P＜0.05). During the treatment，the chemotherapeutic toxic reactions in the observation group were significantly fewer than those in the control group，the difference being significant(Z=-5.049，P=0.000). Conclusion：Shenqi Fuzheng tang can obviously improve the immune function and the levels of cytokines in patients with gastric cancer in stage III to IV，reduce the chemotherapeutic toxic reactions and enhance the quality of life.