Abstract： Objective： To screen the main effective components of Caulis Sargentodoxae by using network pharmacology；to predict the relevant targets of those effective components，and to explore the mechanism of "effective component—target—pathway" effect model of Caulis Sargentodoxae on endometriosis. Methods：The chemical components of Caulis Sargentodoxae were searched through the database of Chinese herbal chemical components， and the active components were screened according to the oral bioavailability(OB) and drug- like index(DL). The targets of each effective component were screened by Targets Information Software. The endometriosis- related target genes were collected by GeneCards database， and the effective components of Caulis Sargentodoxae in treating endometriosis were obtained through the Venn diagram tool. The "effective component—target" network diagram of Caulis Sargentodoxae was constructed by Cytoscape Software，and the relationship between target proteins was analyzed by STRING Software. The GO bioanalysis function of target gene enrichment was analyzed through Geneontology database，and the signal pathways of target gene enrichment were analyzed through KEGG database. Results： In this study， four effective components of Caulis Sargentodoxae were screened out， and 20 related targets in treating endometriosis were obtained， including TGFB1， SLC6A4，PTGS2，PTGS1，PPARG，PON1 and PIK3CG. We found that Caulis Sargentodoxae might treat endometriosis by regulating biological processes like intracellular estrogen receptor signaling pathway，platelet formation，B-cell homeostasis， T- cell homeostasis， cyclooxygenase pathway， ovulation， and KEGG pathways like estrogen signaling pathway， cell apoptosis，arachidonic acid metabolism，VEGF signaling pathway，IL-17 signaling pathway and tumor necrosis factor signaling pathway. Conclusion：From the perspective of network pharmacology，this study preliminarily verified the main targets and related pathways of Caulis Sargentodoxae in the treatment of endometriosis， laying a foundation for further experimental research and clinical application.